Results 31 to 40 of about 705,910 (335)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Engineering Applications of Computational Fluid Mechanics, 2023 Shaft structures in high-rise buildings may increase fire coverage due to chimney effects. However, few previous studies have considered the motion of the flue gas under the combined effect of the chimney effect and thermal buoyancy.
Huimin Cui +4 more
doaj +1 more source
, 1977 A mechanical sequencer having a rotatable drive shaft is described. The drive shaft has a spline formed thereon. A freely rotatable shaft contains a plurality of rollers positioned thereon, the axis of the freely rotatable shaft having an axis parallel ...
Appleberry, W. T.
core +1 more source
TMC4 localizes to multiple taste cell types in the mouse taste papillae
FEBS Open Bio, EarlyView.Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata +6 more
wiley +1 more source
Detailed Modeling of the Direct Reduction of Iron Ore in a Shaft Furnace
Materials, 2018 This paper addresses the modeling of the iron ore direct reduction process, a process likely to reduce CO2 emissions from the steel industry. The shaft furnace is divided into three sections (reduction, transition, and cooling), and the model is two ...
Hamzeh Hamadeh, O. Mirgaux, F. Patisson
semanticscholar +1 more source
, 1992 Described here is a latching device for latching two items together that has a housing and a shaft mounted to one item such that rotation of the shaft by a sprocket causes the shaft to move longitudinally up and down.
Milam, Malcolm B.
core +1 more source
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
FEBS Open Bio, EarlyView.We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source
Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2017 The torsion of a shaft by rigid disks is considered. The shaft has the form of circular cylinder. Two rigid disks are attached to its end faces. The process of continuous growth of such shaft under the influence of twisting torques applied to the disks ...
Alexander V. Manzhirov +2 more
doaj +3 more sources
Current situation and development trend of mechanized shaft driving in frozen shaft
Meitan kexue jishuIn view of the energy occurrence structure of “rich coal, poor oil and little gas” in China, and the situation that coal will occupy the dominant position of energy consumption for a long time,The development history of frozen shaft mechanized drilling ...
Xiangsheng CHEN +6 more
doaj +1 more source
Adjustable locking device [PDF]
, 1972 Adjustable locking device is used for taking up end play of shaft without displacing shaft radially. Coincidentally threaded collars fastened to one or both ends of shaft are threaded in and out of one another for adjustment of end play.
Fincannon, O. J.
core +1 more source