Results 41 to 50 of about 55,764 (261)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

An Analytical Solution for Block Toppling Failure of Rock Slopes during an Earthquake

Applied Sciences, 2017
Toppling failure is one of the most common failure types in the field. It always occurs in rock masses containing a group of dominant discontinuities dipping into the slope.
Songfeng Guo, Shengwen Qi, Guoxiang Yang, Shishu Zhang, Charalampos Saroglou   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

振动台导轨不平顺对地震计低频测试结果的影响

Dizhen xuebao, 2023
对振动台在大行程移动过程中导轨不平顺引起的倾斜效应进行了理论分析，选择0.1 Hz及以下频点开展振动台导轨不平顺引起的台面倾斜对测试结果影响的定量化分析。结果表明，振动台面在移动过程中的不确定倾斜对地震计水平分量灵敏度的影响大于对垂直分量灵敏度的影响。采用高精度水平仪获取水平振动台在不同行程下的运动轨迹起伏变化，并基于倾斜效应的影响机制，用Labview语言实现补偿系统，在地震计的振动测试中对测试结果进行动态补偿。测试结果表明，经过动态补偿，导轨不平顺不再对灵敏度校准结果存在明显制约 ...
Jiemei Ma, Xiaoyong Fan, Wen He
doaj   +1 more source

Re-liquefaction of Sand in Shaking Table

IOP Conference Series: Materials Science and Engineering, 2020
Abstract Subsequent aftershocks can induce reliquefaction of sand. In the shaking table experiment, the settlement, the excess pore water pressure and the acceleration response of the sand in the process of reliquefaction were measured. It was found that: (1) the liquefaction resistance of sand was the lowest in the second liquefaction ...
Dikshit Babu Nepal, Jianliang Deng, Jinjian Chen, Tshegofatso Maakoe   +3 more
openaire   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Motion Parameters of a Mechanical Shaking Table and an Application

Pamukkale University Journal of Engineering Sciences, 2013
In this study, 1.5x1.0 m dimensioned shaking table which was designed and built by Geological Engineering Department of Pamukkale University Engineering Faculty is introduced and produced motion parameters are discussed. In order to determine the different engineering purposed model behaviors under earthquake induced dynamic loads, shaking tables are ...
Celik, SB, Aydan, O, Kumsar, H
openaire   +4 more sources

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Stability Analysis and Verification of Real-Time Hybrid Simulation Using a Shake Table for Building Mass Damper Systems

Frontiers in Built Environment, 2020
The building mass damper (BMD) system, which incorporates the concept of a tuned mass damper into a mid-story isolation system, has been demonstrated as an effective system for suppressing structural vibration due to earthquakes. The BMD system separates
Pei-Ching Chen, Meng-Wei Dong, Po-Chang Chen, Narutoshi Nakata   +3 more
doaj   +1 more source