BTKi orelabrutinib improved the outcome of newly-diagnosed PCNS-LBCL by alleviating MyD88<sup>L265P</sup>-induced PIM1 stability. [PDF]
Yuan Y +26 more
europepmc +1 more source
Machine‐Learning Microfluidic Minute‐Scale Microorganism Metrics Monitoring(M6)
ABSTRACT On‐site monitoring of microorganisms remains challenging because of low concentrations, strong background interference, and dynamic aerosol diffusion, particularly for aerosol‐transmitted pathogens. Here, we report a rapid detection platform that integrates a Puri‐focusing microfluidic chip, electrochemical impedance spectroscopy (EIS), and ...
Ning Yang +14 more
wiley +1 more source
Correction: The disruptor of telomeric silencing 1-like (DOT1L) promotes peritoneal fibrosis through the upregulation and activation of protein tyrosine kinases. [PDF]
Tao M +15 more
europepmc +1 more source
A biotin‐modified artificial insertion peptide functionalized three‐dimensional high‐curvature‐TiO2 nano‐interface was engineered in a microfluidic chip to improve the isolation efficiency of small extracellular vesicles (sEVs). This chip balanced affinity, releasability, and extendibility, enabling high‐throughput recovery of sEVs for downstream ...
Le Wang +7 more
wiley +1 more source
Arterial Occlusion Caused by Intimal Flap Elevation After Arteriosclerosis Obliterans Stent Implantation: A Case Report. [PDF]
Zhang L, Lu F, Yin K, Fang Y, Dong J.
europepmc +1 more source
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu +10 more
wiley +1 more source
Automated assessment of coronal lower extremity alignment on long-leg radiographs using a deep-learning model: validation, efficiency gains, and superiority of an edge-based tibial joint-line definition. [PDF]
Jin W +8 more
europepmc +1 more source
sEVs‐circ6718 serves as a promising serum biomarker for gastric cancer early diagnosis and prognosis, promoting malignant transformation in gastric cancer cells and GC‑MSC differentiation into CAFs. sEVs‑circ6718 holds potential as a biomarker for the early diagnosis and prognostic assessment of gastric cancer.
Fan Zhang +7 more
wiley +1 more source
Impact of artificial intelligence on the availability, accessibility, acceptability and quality of ophthalmic disease screening services: a scoping review. [PDF]
Lin S +10 more
europepmc +1 more source

