Results 31 to 40 of about 831,170 (219)
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Assessing Urban Environmental Management Practice with a Scalar Approach. The Shanghai Case
Symphonya, 2011 Shanghai’s urban environmental management in the past three decades has been focused primarily on the environmental problems at the intra-urban level. While this ‘end of pipe’ approach greatly mitigated domestic and industrial pollution, progresses were ...
Wei Tu
doaj +1 more source
Shanghai yufang yixue, 2023 ObjectiveTo understand the internet media information of COVID-19 in Shanghai in 2022， to provide evidence for health administration departments to respond to public health emergencies， and to establish a comprehensive public health media surveillance ...
LU Yinhao +4 more
doaj +1 more source
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
Shiyan dongwu yu bijiao yixue, 2023 There are differences in historical and cultural beliefs, development history, and levels of technological development among different countries and regions around the world.
ZHAO Yong
doaj +1 more source
BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells
FEBS Open Bio, EarlyView.BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley +1 more source
The Rockefeller Foundation’s Unrealized “Shanghai Medical School” Plan and Its Implications (1915–1920) [PDF]
UisahakThis study aims to explore the Rockefeller Foundation (RF)’s vision for medical education in China through an analysis of the “Shanghai Medical School” proposal and to evaluate the implications of its abandonment on both medical education in Shanghai and
Jeongeun JO
doaj +1 more source
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Simulation of extreme compound coastal flooding in Shanghai
Shui kexue jinzhan, 2019 Estuary deltas and coastal cities are facing with the rising risk of the compound flooding due to the coincidence of storm surge,extreme precipitation,high tide and high river discharge. A new integrated numerical modeling system,which coupled atmosphere,
WANG Luyang +5 more
doaj +1 more source