Results 31 to 40 of about 7,382,212 (297)

An engineered U7 small nuclear RNA scaffold greatly increases ADAR-mediated programmable RNA base editing

Nature Communications
Custom RNA base editing exploiting the human Adenosine Deaminase Acting on RNA (ADAR) enzyme may enable therapeutic gene editing without DNA damage or use of foreign proteins.
Susan M. Byrne, Stephen M. Burleigh, Robert Fragoza, Yue Jiang, Yiannis Savva, Ricky Pabon, Evan Kania, Joseph Rainaldi, Andrew Portell, Prashant Mali, Adrian W. Briggs   +10 more
doaj   +1 more source

Thermal Fatigue Life Prediction under Temperature Uncertainty for Shot Sleeve of Squeeze Casting Machine

Metals, 2021
To quantify the influence of temperature uncertainty on thermal fatigue life prediction of a shot sleeve in an injection mechanism, an uncertainty analysis method based on a Kriging surrogate model and Monte Carlo simulation (MCS) was proposed.
Dongdong You, Wenbin Pang, Dongqing Cai
doaj   +1 more source

Shaping speech [PDF]

Down Syndrome Research and Practice, 2007
Clear speech can often be challenging for people with Down syndrome. The shape of the hard palate in the top of the mouth influences speech production. A new paper reports detailed measures of the shape and size of the hard palate among children with Down syndrome.
openaire   +2 more sources

Shape Theory

Journal of Mathematical Sciences, 2021
Shape theory was founded by K.~Borsuk 50 years ago. In essence, this is spectral homotopy theory; it occupies an important place in geometric topology. The article presents the basic concepts and the most important, in our opinion, results of shape theory.
openaire   +2 more sources

Perceptually Motivated Shape Context Which Uses Shape Interiors

, 2012
In this paper, we identify some of the limitations of current-day shape matching techniques. We provide examples of how contour-based shape matching techniques cannot provide a good match for certain visually similar shapes.
Kakarala, Ramakrishna, Premachandran, Vittal   +1 more
core   +1 more source

Observing Shape in Spacetime [PDF]

, 2014
The notion of "reference frame" is a central theoretical construct for interpreting the physical implications of spacetime diffeomorphism invariance in General Relativity.
Gryb, Sean
core   +4 more sources

Communication and Language Profiles of Children Treated for Posterior Fossa Brain Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cognitive and language deficits are frequently reported sequelae of posterior fossa brain tumors (PFBT). Typically, delayed onset impedes prompt assessment and early intervention. This has devastating implications for quality of life.
Zara Sved, Meghan Hesse, Jennie Cusiter, Annabel Webb, Kimberley Docking   +4 more
wiley   +1 more source

Effect of the Shape of Stator Blades on the Performance Output of a Vertical Axis Marine Current Turbine [PDF]

, 2013
Due to the diminishing reserves of fossil fuels and increased pollution from exploitation of these fuels, the world is focusing on the renewable energy sources.
Asim, Taimoor, Mishra, Rakesh, Ubbi, Kuldip   +2 more
core   +1 more source

Subjectively interpreted shape dimensions as privileged and orthogonal axes in mental shape space [PDF]

, 2011
The shape of an object is fundamental in object recognition but it is still an open issue to what extent shape differences are perceived analytically (i.e., by the dimensional structure of the shapes) or holistically (i.e., by the overall similarity of ...
De Baene, Wouter, Ons, Bart, Wagemans, Johan   +2 more
core   +1 more source

The HIT Network for Children and Adolescents With CNS Tumors Facilitates Improvements of Diagnostic Assessments, Multimodal Treatments, Individual Counseling, and Research in Germany, Austria, and Switzerland

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The HIT network was established in 2000 to create a population‐based structure aiming to improve survival rates and reduce late effects for children with central nervous system (CNS) tumors by conducting comprehensive clinical trials.
Stefan Rutkowski, Michael C. Frühwald, Gudrun Fleischhack, Stephan Tippelt, Pablo Hernáiz‐Driever, Olaf Witt, Astrid Gnekow, Christof Kramm, Matthias Eyrich, Johannes E. A. Wolf, Hermann Müller, Carsten Friedrich, Uwe R. Kordes, Denise Obrecht‐Sturm, Petra Ketteler, Barbara von Zezschwitz, Pascal Johann, Dominik Sturm, Karoline Nemes, Stefan Schönberger, Till Milde, Brigitte Bison, Monika Warmuth‐Metz, Torsten Pietsch, Ulrich Schüller, Arend Koch, David Capper, Martin Hasselblatt, Christian Thomas, Christian Hagel, Stefan M. Pfister, Felix Sahm, David T. W. Jones, Martin U. Schuhmann, Jürgen Krauss, Pedram Emami, Ahmed El Damaty, Rolf D. Kortmann, Rudolf Schwarz, Jürgen Debus, Mechthild Krause, Fabian Pohl, Holger Ottensmeier, Lisa Bußenius, Katja Baust, Andreas Faldum, Cecile Ronckers, Desiree Grabow, Martin Benesch, Thomas Perwein, Karin Dieckmann, Irene Slavc, Johannes Gojo, Nicolas U. Gerber, André O. von Bueren, Katrin Scheinemann, Gabriele Calaminus, Beate Timmermann, Ulrich‐Wilhelm Thomale, Martin Mynarek   +59 more
wiley   +1 more source