Results 211 to 220 of about 1,418,325 (264)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Multiconstraint shape analysis

Image and Vision Computing, 1986
Abstract The paper presents a method for applying multiple semantic constraints based on discrete relaxation. A separate graph is maintained for each constraint relation and used in parallel to achieve consistent labelling. This permits both local and global analysis without recourse to complete graphs.
Tom Henderson, Ashok Samal
openaire   +1 more source

Branch Profiles for Shape Analysis

2020 Digital Image Computing: Techniques and Applications (DICTA), 2020
The necessity for characterising highly irregularly shaped objects appears in many circumstances, most prominently in biology and medicine, but also in physical sciences and elsewhere. Here, a multi-scale method for quantifying the level of branching in irregular structures is presented to extend the repertoire descriptors of shape. The method was used
Zayed M. Asiri   +2 more
openaire   +3 more sources

SHAPE MODELING AND SHAPE ANALYSIS BASED ON SINGULARITIES

International Journal of Shape Modeling, 1996
Summary: To analyze given object shapes, it is necessary first to model the shapes and then to analyze the models. This paper proposes a method of modeling and analyzing two-dimensional (2D) and three-dimensional (3D) shapes based on singularities. First, a function is defined on an object.
Yoshihisa Shinagawa   +3 more
openaire   +2 more sources

Indirect shape analysis for 3D shape retrieval

Computers & Graphics, 2015
We introduce indirect shape analysis, or ISA, where a given shape is analyzed not based on geometric or topological features computed directly from the shape itself, but by studying how external agents interact with the shape. The potential benefits of ISA are two-fold.
Zhenbao Liu   +6 more
openaire   +1 more source

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