Results 241 to 250 of about 24,822,268 (298)

Predicting Occluded Middle Cerebral Artery Morphology for Endovascular Mechanical Thrombectomy: A Contralateral Shape Analysis Approach. [PDF]

Asian J Neurosurg
Takenoya N, Oya S, Watanabe T, Shojima M, Matsui T, Yoshino Y.   +5 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Leveraging Machine Learning for Size and Shape Analysis of Nanoparticles: A Shortcut to Electron Microscopy. [PDF]

J Phys Chem C Nanomater Interfaces
Glaubitz C, Bazzoni A, Ackermann-Hirschi L, Baraldi L, Haeffner M, Fortunatus R, Rothen-Rutishauser B, Balog S, Petri-Fink A.   +8 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Clinical performance and shape analysis of trifocal intraocular lenses via scanning electron microscopy. [PDF]

BMC Ophthalmol
Yamashita K, Hayashi K, Hata S.
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

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Multiconstraint shape analysis

Image and Vision Computing, 1986
Abstract The paper presents a method for applying multiple semantic constraints based on discrete relaxation. A separate graph is maintained for each constraint relation and used in parallel to achieve consistent labelling. This permits both local and global analysis without recourse to complete graphs.
Tom Henderson, Ashok Samal
openaire   +2 more sources

Learning Shape Analysis

2017
We present a data-driven verification framework to automatically prove memory safety of heap-manipulating programs. Our core contribution is a novel statistical machine learning technique that maps observed program states to (possibly disjunctive) separation logic formulas describing the invariant shape of (possibly nested) data structures at relevant ...
Marc Brockschmidt, Yuxin Chen 0001, Pushmeet Kohli, Siddharth Krishna 0001, Daniel Tarlow   +4 more
openaire   +1 more source