Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Emerging Adults' Experiences of Digital Measurement-Based Care in Routine Mental Health Care: Qualitative Study and Conceptual Synthesis. [PDF]
Henry G +12 more
europepmc +1 more source
Adenosine triphosphate as a modulator of protein interactions and stability
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley +1 more source
Hospital-to-home transitions for children with medical complexity. [PDF]
Mitevska E, Luyimbazi E, Do V.
europepmc +1 more source
Silent Pain or Silent Records? Pain Visibility, Documentation Ethics, and Nursing Management in Neurocritical Care. [PDF]
Li Z, You J, Zhang L, Ma B, Liu Y.
europepmc +1 more source
Single Anesthetic Approach to Diagnosis, Staging and Treatment of Lung Cancer. [PDF]
Aizpuru M, Wittenberg J, Reisenauer J.
europepmc +1 more source
Reframing Rehabilitation Retention in Long-Term Conditions: A Theory-Informed Mini-Review of Psychological Adaptation and Engagement. [PDF]
Khoshraftar M +4 more
europepmc +1 more source
Influence of Research Years and Subinternships on the 2025 Integrated Plastic Surgery Match. [PDF]
Stanton WN +3 more
europepmc +1 more source
Cross-modal semantic scene completion for complex urban traffic scenes with reachability geometric attention. [PDF]
Zhan B +5 more
europepmc +1 more source

