Results 141 to 150 of about 6,713,628 (313)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Shape design for controlling structural displacement distribution in unsteady fluid-structure-interaction

Mechanical Engineering Journal
This paper presents a numerical solution for the shape design problem in unsteady fluid-structure-interaction (FSI) fields with viscous flow. The FSI analysis uses a strongly coupled approach based on the Arbitrary Lagrange-Eulerian (ALE) method.
Shota NARUSE, Eiji KATAMINE
doaj   +1 more source

Shape Machine and Architecture Theory

, 2019
Presented as part of the Shape Machine Symposium on April 11, 2019 at 11:30 a.m. in theJohn & Joyce Caddell Building, Flex Space.Heather Ligler is an architect and design researcher interested in how generative and parametric design both provide a new ...
Ligler, Heather
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

On the existence of the shape derivative of solutions of boundary value problems using Minkowski deformation

In this work, we show the existence of the shape derivative of the solution of Laplacian Dirichlet and Neumann boundary value problems using the Minkowski deformation of convex domains by convex ones.
Chakib, Abdelkrim, Sadik, Azeddine, Boulkhemair, Abdesslam   +2 more
core   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Modulation Instability, Analytical, and Numerical Studies for Integrable Time Fractional Nonlinear Model through Two Explicit Methods

Advances in Mathematical Physics
The present work deals with the investigation of the time-fractional Klein–Gordon (K-G) model, which has great importance in theoretical physics with applications in various fields, including quantum mechanics and field theory.
Md. Mamunur Roshid, Mosfiqur Rahman, Mahtab Uddin, Harun Or Roshid   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

On the solutions of generalized Cauchy differential equations and diffusion equations with k-Hilfer-Prabhakar derivative

Partial Differential Equations in Applied Mathematics
In this article, natural transform of k-Prabhakar integral, k-Prabhakar derivative, k-Hilfer-Prabhakar fractional derivative (k-HPFD) are calculated. In addition, we also obtain the natural transform of regularized versions of k-Prabhakar integral, k ...
Ved Prakash Dubey, Jagdev Singh, Sarvesh Dubey, Dumitru Baleanu, Devendra Kumar   +4 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source