Results 201 to 210 of about 20,905 (259)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Predicting Blood-Brain Barrier Permeability from Experimental Data: An Interpretable and Externally Validated Machine Learning Framework. [PDF]

Pharmaceutics
Tiwari S, Mądra-Gackowska K, Gackowski M, Park N, Szeleszczuk Ł.   +4 more
europepmc   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Human Endothelial Membrane as a Structural Prototype: A Comparative Analysis with <i>Artemia salina</i> Endothelial-like Cell. [PDF]

Int J Mol Sci
Lungu CN, Basak SC, Creteanu A, Putz MV, Romila A, Nechita A, Gurau G, Mehedinti MC.   +7 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Distribution-preserved sampling (DPS) for smarter machine learning assisted ultra-large-scale virtual screening. [PDF]

RSC Adv
Trachtenberg A, Spelkov A, Akabayov B.
europepmc   +1 more source

An Effective Non-Rigid Registration Approach for Ultrasound Images Based on the Improved Variational Model of Intensity, Local Phase Information and Descriptor Matching. [PDF]

J Imaging
Zhang K, Xing J, Xiao Q.
europepmc   +1 more source

Shapes of synaptic protein distributions distinguish brain architectures

Rehn M, Cizeron M, Qiu Z, Grant SGN, Fransén E.   +4 more
europepmc   +1 more source

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Robust Affine Invariant Region-Based Shape Descriptors: The ICA Zernike Moment Shape Descriptor and the Whitening Zernike Moment Shape Descriptor

IEEE Signal Processing Letters, 2009
In this letter, we proposed two new affine invariant region-based shape descriptors, the ICA Zernike moment shape descriptor (ICAZMSD) and the whitening Zernike moment shape descriptor (WZMSD). Either independent component analysis (ICA) or whitening, is first used to turn the original shape into a canonical form, in which the effects of scaling and ...
Dimitrios Androutsos
exaly   +2 more sources

A fast shape descriptor

Computer Vision, Graphics, and Image Processing, 1986
A new fast shape descriptor, based upon the rapid transformation of Reitboeck and Brody, is presented. The normalized rapid descriptors (NRD) developed here and normalized Fourier descriptors (NFD) are applied to the analyses of some typical 2D images. It is shown that they both have good recognition performance.
Jun Ma, Chengke Wu 0001, Xin-Ru Lu
openaire   +2 more sources