Results 281 to 290 of about 2,841,987 (371)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Directional Entropy Bands for Surface Characterization of Polymer Crystallization. [PDF]

Polymers (Basel)
Tourani E, Edwards BJ, Khomami B.
europepmc   +1 more source

Moment of inertia as a simple shape descriptor for diffusion-based shape-constrained molecular generation

Denis Andzheevich Sapegin, F. L. Bakharev, Dmitry Krupenya, Azamat Gafurov, Konstantin Pildish, Joseph C. Bear   +5 more
openalex   +2 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Does attitude importance moderate the effects of person-first language? A registered report. [PDF]

PLoS One
Schumann S, Zohny H.
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Machine Learning-Guided Design of Rhenium Tricarbonyl Complexes for Next-Generation Antibiotics. [PDF]

ACS Bio Med Chem Au
Nedyalkova M, Demirci G, Cortat Y, Schindler K, Rahmani F, Horner J, Vasighi M, Crochet A, Pavic A, Mamula O, Zobi F, Lattuada M.   +11 more
europepmc   +1 more source

Morpho-Agronomic Characterization of an Unexploited Germplasm Collection of Cauliflower (<i>Brassica oleracea</i> var. <i>botrytis</i> (L.)) from Spain. [PDF]

Plants (Basel)
Prendes-Rodríguez E, Iborra A, Guijarro-Real C, Rodríguez-Burruezo A, Fita A.   +4 more
europepmc   +1 more source

Recent Advances in Machine Learning Models for Predicting Toxicity of Inorganic Nanoparticles. [PDF]

Chem Bio Eng
Li M, Li QZ, Zhao Y, Gao X.
europepmc   +1 more source

Classification of differentially activated groups of fibroblasts using morphodynamic and motile features. [PDF]

APL Bioeng
Kang M, Min C, Devarasou S, Shin JH.
europepmc   +1 more source