Results 231 to 240 of about 1,732,484 (345)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Community detection framework based on 3D shape descriptors for tree species classification in point cloud data. [PDF]

Sci Rep
Kohek Š, Žalik B, Mongus D, Strnad D.
europepmc   +1 more source

Object Detection and Sorting by Using a Global Texture-Shape 3D Feature Descriptor.

, 2018
Zhun Fan, Zhongxing Li, Wenji Li
openalex   +1 more source

Social competition shapes motor response execution and inhibition in a Go/NoGo task: Behavioral, signal-detection, and ERP evidence [PDF]

Yong Li, Cuihong Liu, Guoliang Chen, Bing Zhang   +3 more
openalex   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

A large-scale and flexible SERS substrate based on sliver decorated nano-cone arrays and its applications for pesticide residue detection. [PDF]

RSC Adv
Chen J, Hu M, Liu T, Huang M, Kong L, Yu X, Sun Q.   +6 more
europepmc   +1 more source

Shape-Induced Enhanced Raman Scattering (SIERS) PlatformsModified with Gold Nanorods for Ultradiluted Atrazine Pesticide Detection

Matheus Gomes Ferreira (21352824), Anerise de Barros (9132865), Flavio Makoto Shimizu (9132868), Fernando Aparecido Sigoli (1492807), Carlos César Bof Bufon (8712630), Italo Odone Mazali (1492813)   +5 more
openalex   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Effect of inclusion lagrange interpolation method in mode shape curvature based damage detection

, 2019
C M Hasrizam, Noor Fawazi
openalex   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source