Results 111 to 120 of about 16,300 (265)

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

open access: yesAdvanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng   +16 more
wiley   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

open access: yesAdvanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen   +7 more
wiley   +1 more source

Sticker Valence Governs Chain Collapse and Liquid‐Liquid Phase Separation in Peptide‐Inspired Associative Polymers

open access: yesAdvanced Science, EarlyView.
Peptide‐inspired associative polymers with arginine‐like guanidinium stickers and lysine‐like ammonium spacers undergo chain collapse and liquid‐liquid phase separation induced by reversible sticker associations. Sticker valence and tunable association strength jointly control the phase behavior, chain conformation, and interfacial cohesion of these ...
Seung‐Hwan Oh   +7 more
wiley   +1 more source

Application of Symbolic Language and Pattern Innovation of Chaoshan Peach Cake Mold in Paper Packaging Design

open access: yesBioResources
To explore the symbolic language of the Chaoshan peach cake mold and its innovative applications in modern design, the material form and cultural connotations of the mold patterns were analyzed from a semiotic perspective.
Jiahang Chen
doaj  

Ru‐Doping‐Engineered Oxygen Vacancies in MoO3‐x Nanostructured Films With Ultrahigh Capacitance for Flexible Asymmetric Supercapacitors

open access: yesAdvanced Science, EarlyView.
Ru‐doping‐induced defect engineering enables freestanding Ru–MoO3‐x flexible films with enriched oxygen vacancies, modulated band structure, and enhanced charge transport. The optimized electrode delivers ultrahigh capacitance approaching the theoretical limit of MoO3, while assembled asymmetric supercapacitors exhibit high energy density, wide‐voltage
Xiaoqing Bin   +8 more
wiley   +1 more source

A geometric and probabilistic framework for mechanistic antifungal screening from colony morphology. [PDF]

open access: yesPest Manag Sci
Ahn E   +10 more
europepmc   +1 more source

Tailored Covalent Organic Frameworks Enable the Encapsulation of Living Cells to Produce Rare Ginsenoside

open access: yesAdvanced Science, EarlyView.
This work reports the in situ fabrication of Escherichia coli@covalent organic frameworks (E. coli@COFs) in phosphate‐buffered saline. The COFs form an exoskeleton on E. coli, protecting intracellular β‐glucosidase (Ssbgl) while enhancing mass transfer.
Fengmei Liu   +6 more
wiley   +1 more source

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