Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Analysing functional implications of differences in left ventricular morphology using statistical shape modelling. [PDF]
Sci Rep, 2022 Sophocleous F +9 more
europepmc +1 more source
Computational morphogenesis of free form shells: Filter methods to create alternative solutions [PDF]
, 2009 p. 536-547Actual trends in numerical shape optimal design of structures deal with handling of very large dimensions of design space. The goal is to allowing as much design freedom as possible while considerably reducing the modelling effort.
BLETZINGER, Kai-Uwe +3 more
core +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Modelling of an irregular shape cargo allocated in open wagon [PDF]
Transport Problems, 2009 The article gives the account of the results of calculation of stretches in flexible resilient elements of fastenings on the lower, inaccessible for pretwisting, irregular shape cargo section transported in an open wagon, depending upon initial value of ...
Elena TIMUKHINA
doaj
Statistical shape modelling of the thoracic spine for the development of pedicle screw insertion guides. [PDF]
Biomech Model Mechanobiol, 2023 Wai G +5 more
europepmc +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Generation of hemipelvis surface geometry based on statistical shape modelling and contralateral mirroring. [PDF]
Biomech Model Mechanobiol, 2022 Krishna P +3 more
europepmc +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Shaping sustainable business models
, 2020 Recent economic crises, environmental problems and social challenges have urged us to drastically change our consumption and production patterns and transform organisations to contribute to socio-technical transitions that positively impact these challenges.
openaire +2 more sources