Results 171 to 180 of about 1,006,629 (202)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

The shape of the systolic blood pressure response during graded exercise: methodology, correlates and predictive value. [PDF]

J Hum Hypertens
Cauwenberghs N, Carlén A, Lindow T, Elmberg V, Brudin L, Ekström M, Hedman K.   +6 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A Longitudinal Analysis of a Motor Skill Parameter in Junior Triathletes from a Wearable Sensor. [PDF]

Sensors (Basel)
Chesher SM, Chapman DW, Liew B, Rosalie SM, Riddell H, Charlton PC, Netto KJ.   +6 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Analysis of Roll Pass Wear in the Railway Rail Rolling Process. [PDF]

Materials (Basel)
Szota P, Mróz S, Stefanik A, Zygmunt T, Bołda M.   +4 more
europepmc   +1 more source

How complex must shape data be to model in vivo forces? Intraspecific level validation of in silico jaw strength estimates in a lizard. [PDF]

J Exp Biol
Woodgate SC, Pérez-Cembranos A, Pérez-Mellado V, Müller J.   +3 more
europepmc   +1 more source

Assessing the impact of bacterial heterogeneity on bacteriophage population dynamics. [PDF]

J Pharmacokinet Pharmacodyn
Beldjenna M, Guedj J, van Hasselt JGC, Guo T.   +3 more
europepmc   +1 more source

Behavioral and social pathways of adolescent drug use in Indonesia: implications for community-based prevention. [PDF]

BMC Public Health
Azwar M, Hamdan DF, Iskandar R, Widiastuty L, Adnan Y.   +4 more
europepmc   +1 more source