Results 171 to 180 of about 130,134 (311)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

An Annotation-Free Pipeline for 3D Auricular Bowl Atlas Construction and Statistical Shape Modelling from Surface Scans. [PDF]

Sensors (Basel)
Zhang T, Lee TKW, Huang J, Leung KL, Fu SN.   +4 more
europepmc   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Parametrized statistical appearance and shape modelling strategy to predict proximal and diaphyseal femoral fractures. [PDF]

Front Bioeng Biotechnol
Cebeci Ö, Cronin DS, Checa S.
europepmc   +1 more source

High quality statistical shape modelling of the human nasal cavity and applications. [PDF]

R Soc Open Sci, 2018
Keustermans W, Huysmans T, Danckaers F, Zarowski A, Schmelzer B, Sijbers J, Dirckx JJJ.   +6 more
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Morphology and calcification characterization in patients undergoing TAVI: A 3D statistical shape modelling study. [PDF]

PLOS Digit Health
Sivera R, Montgomery-Liljeroth E, Chen Y, Schievano S, Brüning J, Huberts W, Mathur A, Cook A, Patel K, Capelli C.   +9 more
europepmc   +1 more source

The effect of articular geometry features identified using statistical shape modelling on knee biomechanics. [PDF]

Med Eng Phys, 2019
Clouthier AL, Smith CR, Vignos MF, Thelen DG, Deluzio KJ, Rainbow MJ.   +5 more
europepmc   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Combining deep learning with statistical shape modelling enables automated lower limb measurements with observer-level reliability using weight-bearing computed tomography. [PDF]

J Exp Orthop
Van den Borre I, Audenaert E, Vermue H, Huysentruyt R, Van Vynckt L, Vanhauwe R, Pas V, Pizurica A, Van Oevelen A.   +8 more
europepmc   +1 more source