Results 71 to 80 of about 130,134 (311)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Modelling of cutting fibrous composite materials: current practice [PDF]

open access: yes, 2015
Using fibre reinforced polymers (FRP) is increasing across many industries. Although FRP are laid-up in the near-net shape, several cutting operations are necessary to meet quality and dimensional requirements.
Kahwash, Fadi   +5 more
core   +1 more source

Twists and turns

open access: yeseLife, 2017
Computational modelling of the heart tube during development reveals the interplay between tissue asymmetry and growth that helps our hearts take shape.
Emily S Noël, Jeroen Bakkers
doaj   +1 more source

RANGE AND IMAGE BASED MODELLING: A WAY FOR FRESCOED VAULT TEXTURING OPTIMIZATION [PDF]

open access: yesThe International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2015
In the restoration of the frescoed vaults it is not only important to know the geometric shape of the painted surface, but it is essential to document its chromatic characterization and conservation status.
G. Caroti   +2 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Procedural function-based modelling of volumetric microstructures

open access: yes, 2011
We propose a new approach to modelling heterogeneous objects containing internal volumetric structures with size of details orders of magnitude smaller than the overall size of the object.
Fryazinov, Oleg   +9 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Modelling nonlinear dynamics of shape-memory-alloys with approximate models of coupled thermoelasticity

open access: yes, 2003
© 2003 WILEY-VCH Verlag GmbH & Co.AbstractWe present a general methodology for constructing approximate models describing shape memory alloys dynamics.
Melnik, R.   +3 more
core   +1 more source

New Star-Like Surfacetexture for Enhanced Hydrodynamic Lubrication Performance

open access: yesArchives of Metallurgy and Materials, 2017
This paper presents a numerical modelling and optimization of a new ‘star-like’ geometric texture shape with an aim to improve tribological performance.
Uddin M.S., Liu Y.W., Shankar S.
doaj   +1 more source

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