Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
ACCURATE REGISTRATION BETWEEN ULTRA-WIDE-FIELD AND NARROW ANGLE RETINA IMAGES WITH 3D EYEBALL SHAPE OPTIMIZATION. [PDF]
Proc Int Conf Image Proc, 2023 Zhang J +7 more
europepmc +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Genetic algorithm shape optimization to manipulate the nonlinear response of a clamped-clamped beam. [PDF]
Heliyon, 2022 Mollik T +4 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Hull shape optimization for autonomous underwater vehicles using CFD
, 2016 Drag estimation and shape optimization of autonomous underwater vehicle (AUV) hulls are critical to energy utilization and endurance improvement. In the present work, a shape optimization platform composed of several commercial software packages is ...
Wang YX(王亚兴) +3 more
core
PSO-Incorporated Hybrid Artificial Hummingbird Algorithm with Elite Opposition-Based Learning and Cauchy Mutation: A Case Study of Shape Optimization for CSGC-Ball Curves. [PDF]
Biomimetics (Basel), 2023 Chen K, Chen L, Hu G.
europepmc +1 more source
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
Developments in topology and shape optimization
, 2010 Our contribution consists of three parts: a gradient-based parameter-free shape optimization method; a stress-constrained topology optimization; and a wave tailoring topology optimization.
Le, Chau H.
core
Design and Shape Optimization of Strain Gauge Load Cell for Axial Force Measurement for Test Benches. [PDF]
Sensors (Basel), 2022 Al-Dahiree OS +6 more
europepmc +1 more source