Results 111 to 120 of about 2,605,450 (287)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Adaptive Array Shape Estimation and High-Resolution Sensing for AUV-Towed Linear Array Sonar During Turns

The deformation of the array shape during the turning process of an autonomous underwater vehicle (AUV)-towed line array sonar can significantly degrade its remote sensing performance.
Xiang Pan, Jianbo Jiao, Lei Cheng, Junxiong Wang   +3 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Shape sensing endoscope fiber

Optica
Minimally invasive and robotic surgeries are growing areas that benefit patients through reduced recovery time. Medical fiber optics play an important role in these procedures by enabling instrument navigation, imaging, sensing, power delivery, and diagnostics in a small form factor.
Erin S. Lamb, Zhou Shi, Tristan Kremp, David J. DiGiovanni, Paul S. Westbrook   +4 more
openaire   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Shape Sensing in Plate Structures through Inverse Finite Element Method Enhanced by Multi-Objective Genetic Optimization of Sensor Placement and Strain Pre-Extrapolation

Sensors
The real-time reconstruction of the displacement field of a structure from a network of in situ strain sensors is commonly referred to as “shape sensing”. The inverse finite element method (iFEM) stands out as a highly effective and promising approach to
Emiliano Del Priore, Luca Lampani
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

A Novel Sensor Placement Method for High-Aspect-Ratio Unmanned Aerial Vehicle Wings Based on Chaotic Strengthened Aquila Optimizer

Machines
Optimal sensor placement (OSP) is critical to building a full-lifecycle health monitoring network for high-aspect-ratio unmanned aerial vehicle wings, as it directly affects the deformation sensing of the wing shape. To address this challenge, this paper
Pengying Xu, Yu Wang, Shaoyi Liu, Jitang Zhang, Longyang Wang, Chuanmeng Sun, Heming Zhao, Jing Han, Congsi Wang, Yan Wang   +9 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source