Results 201 to 210 of about 2,605,450 (287)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Learning Shape-Sensing Robotic-Assisted Bronchoscopy after Mastering Advanced Image-Guided Navigation Bronchoscopy.

Respiration
Bruinen ARC, Verhoeven RLJ, Hannink G, van der Heijden EHFM.   +3 more
europepmc   +1 more source

Chinese expert consensus on shape-sensing robotic-assisted bronchoscopy (ssRAB) in the management of peripheral pulmonary lesions. [PDF]

Transl Lung Cancer Res
Xie F, Zhang C, Li C, Liu D, Zhang Q, Mu C, Hou G, Li M, Tang C, Xu F, Chen H, Chen Z, Gu Y, Guan Z, Ji C, Li H, Li W, Li X, Li Y, Lian H, Liao J, Luo Z, Ouyang H, Shen Y, Shi Y, Wan N, Wang T, Wang H, Wang H, Wang J, Wu J, Wu X, Xia Y, Xiao K, Xu W, Yang H, Yang J, Ye T, Ye X, Yu P, Zhang N, Zhang P, Zhao Q, Zheng X, Zou J, Chen E, Zhang H, Sun J, Professional Committee on Interventional Pulmonology of China Association for Promotion of Health Science and Technology, Expert Group on Technology of Shape-sensing Robotic-assisted Bronchoscopy.   +49 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Shape Sensing of Continuum Manipulators with Fiber Bragg Grating Sensor Arrays: Accounting for Actuator Velocity Effects. [PDF]

IEEE Sens J
Amirkhani G, Liu X, Armand M.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Impact of Intraoperative C-arm 3D Imaging on the Diagnostic Yield of Robotic Shape-Sensing Navigation Transbronchial Biopsy. [PDF]

Ann Thorac Surg Short Rep
Cambiaghi T, Sarlin S, Santacruz JF, Lee JJ, Kopas L, Chihara R, Kim MP.   +6 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

FBG-based Shape-Sensing to Enable Lateral Deflection Methods of Autonomous Needle Insertion. [PDF]

Rep U S
Lezcano DA, Iordachita II, Kim JS.
europepmc   +1 more source