Results 81 to 90 of about 336,617 (266)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Localization of the Chain Recurrent set using Shape theory and Symbolical Dynamics

open access: yesTopological Algebra and its Applications, 2019
The main aim of this paper is localization of the chain recurrent set in shape theoretical framework. Namely, using the intrinsic approach to shape from [1] we present a result which claims that under certain conditions the chain recurrent set preserves ...
Shoptrajanov M.
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Shape Coexistence in Odd-Z Isotopes from Fluorine to Potassium

open access: yesParticles
The shape of a nucleus is one of its fundamental properties. We conduct a systematic investigation of shape coexistence in odd-Z nuclei from fluorine to potassium using the deformed relativistic Hartree–Bogoliubov theory in continuum. First, we present a
Myeong-Hwan Mun   +2 more
doaj   +1 more source

Effect of rotating speed and stiffeners on natural frequency of composite shell [PDF]

open access: yesفصلنامه علوم و فناوری فضایی, 2011
The effect of rotating speed and stiffeners on vibrations for composite rotors is investigated using Sander's shell theory. The frequency equation is derived implementing the Rayleigh-Ritz procedure based on energy method.
A. A. Jafari   +2 more
doaj  

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