Results 41 to 50 of about 8,211,530 (240)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Shapiro-Wilk test of normality for the standard deviation (SD) values of the kinematic features.

, 2016
Shapiro-Wilk test of normality for the standard deviation (SD) values of the kinematic features.
Kevin D. Donohue (506789), Rita R. Patel (2636092), Harikrishnan Unnikrishnan (2636089)   +2 more
core   +1 more source

Shapiro-Wilks test.

, 2023
Results from Shapiro-Wilks test for normality of the data across all samples. (XLSX)
Zaid Abdo (175649), Bruce Kimball (3475472), James Pierce (699126), Matthew W. Hopken (3251058), Darby Gilfillan (9357456), Amy T. Gilbert (7892561), Mikaela Samsel Hilton (16865950), Antoinette J. Piaggio (7852013)   +7 more
core   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

P-values for Shapiro-Wilk normality test with combined resistance genes.

, 2020
For each condition we test for normality with the Shapiro-Wilk Normality Test. All cases except one (growth rates for isolates with no CTX-M-15 and TEM-1 in presence of cefepime) indicate normality (with p < 0.01).
Jay Kim (230457), Juan Meza (8384427), Miriam Barlow (197488), Manel Camps (204421), Evin Doscher (8384424), Suzanne Sindi (8384430), Fabian Santiago (8384421)   +6 more
core   +1 more source

Comparison of Normality Tests in Terms of Sample Sizes under Different Skewness and Kurtosis Coefficients

International Journal of Assessment Tools in Education, 2022
This study aims to compare normality tests in different sample sizes in data with normal distribution under different kurtosis and skewness coefficients obtained simulatively.
Süleyman Demir
doaj   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Perbandingan Tingkat Konsistensi Normalitas Distribusi Metode Kolmogorov-Smirnov, Lilliefors, Shapiro-Wilk, dan Skewness-Kurtosis [PDF]

, 2014
There are many kinds of normality test method in determining the data whether has the normal distribution or not. Some of these methods result can make different decision so it can be misleading and confusing practitioners in performing statistical ...
Mitha Arvira Oktaviani, -, Hari Basuki Notobroto, -   +1 more
core   +1 more source