Results 111 to 120 of about 2,452,407 (306)
Exploring integrated care for children with cerebral palsy: a stakeholder analysis
BMC Health Services ResearchBackground Children with cerebral palsy (CP) and their families need coordinated services. Accordingly, integrated care models have been introduced as the standard for service provision.
Silje Askeland +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Comparative evaluation of an AI-powered life coach against traditional coaching methods
International Journal of Evidence Based Coaching and MentoringThis study assesses the efficacy of “1440”, an AI-powered life coaching tool, in comparison to traditional human coaching. Utilizing a controlled experimental design, participants were divided into three distinct groups and engaged in a standardized ...
David Brown, Marlene Orozco, Noah Lloyd
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
UK corporate share repurchases: an empirical analysis of corporate motives and payout policies [PDF]
, 2007 This thesis investigates the motives behind share buybacks in the UK, and examines this form of corporate payout in relation to dividends by extending traditional corporate dividend behaviour models to include payouts made through share repurchases ...
Benhamouda, Zoubeida
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The spatial shift-share analysis - new developments and some findings for the Spanish case [PDF]
The main feature of shift-share analysis is, according to Dunn (1960), the computation of geographical shifts in economic activity. Nevertheless, the traditional shift-share approach does not include explicitly the interaction between the considered ...
Ana Jesús López Menéndez +1 more
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Share repurchase regulations: do firms play by the rules? [PDF]
Open market share repurchases are strictly regulated to prevent companies from profiting from insider information. We examine compliance with these rules in France, where the mandatory disclosure of share repurchases provides detailed information on ...
Jacques Hamon, Edith Ginglinger
core