Results 41 to 50 of about 2,452,407 (306)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Sharing a River [PDF]

Journal of Economic Theory, 2002
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Ambec, Stefan, Sprumont, Yves
openaire   +6 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Identifying, categorising, and mapping actors involved in resilience in healthcare: a qualitative stakeholder analysis

BMC Health Services Research
Background Resilience in healthcare is the capacity to adapt to challenges and changes to maintain high-quality care across system levels. While healthcare system stakeholders such as patients, informal carers, healthcare professionals and service ...
Veslemøy Guise, Mary Chambers, Hilda Bø Lyng, Cecilie Haraldseid-Driftland, Lene Schibevaag, Birte Fagerdal, Heidi Dombestein, Eline Ree, Siri Wiig   +8 more
doaj   +1 more source

The Responsibility to Share: Sharing the Responsibility [PDF]

Genome Research, 2004
domains or epitope tags). This flexibility means that initial clone sets will become the basis for many rounds of subcloning to permit finer experimental definition of function. The simplicity of these methods and the growth of bioinformatics and robotics facilitate production of large-scale clone sets whose experimental value increases geometrically ...
Martin, Yuille, Bernhard, Korn, Troy, Moore, Andrew A, Farmer, John, Carrino, Christa, Prange, Yoshihide, Hayashizaki   +6 more
openaire   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

TO SHARE OR NOT TO SHARE

, 2017
We observe a rise of new business models that embed different forms of sharing. This topic has hardly been picked up by innovation research and particularly in the user innovation research community, except for online open-source communities. This paper sets out to link users’ sharing behavior to users’ innovation behavior.
Pieper, Thorsten, Tietze, Frank, Schultz, Carsten, Herstatt, Cornelius   +3 more
openaire   +2 more sources

To Share or Not to Share: Demand Forecast Sharing in a Distribution Channel [PDF]

SSRN Electronic Journal, 2014
This paper studies information sharing in a distribution channel where the manufacturer possesses better demand-forecast information than the downstream retailer. We examine three information-sharing formats: no information sharing (i.e., the manufacturer ex ante commits to not sharing its forecast), voluntary information sharing (i.e., the ...
Baojun Jiang, Lin Tian, Yifan Xu, Fuqiang Zhang   +3 more
openaire   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source