Results 41 to 50 of about 5,495 (233)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Physician‐Scientist Pipeline for Pediatric Rheumatology: The Current Landscape and Future Perspectives

open access: yesArthritis Care &Research, EarlyView.
Over the past 50 years, the science of pediatric rheumatology has grown exponentially due to an expansion in the understanding of complex rheumatic conditions and a surge in novel targeted therapeutics. Physician‐scientists in the field of pediatric rheumatology have played major roles in these advancements that have improved the care of children ...
Ekemini A. Ogbu   +2 more
wiley   +1 more source

When do toddlers point during mealtime?: Pointing in the second year of life in everyday situations

open access: yesFrontiers in Psychology, 2023
The present study aimed to gain insight into the development of the infant’s awareness of others’ attention that takes place in everyday contexts. We examined the relation between the toddler’s pointing, the toddler’s visual attention to the caregiver ...
Jun Kasuya, Tetsushi Nonaka
doaj   +1 more source

Engagement Patterns with an AI Health Coach for Systemic Sclerosis Self‐Management: A Mixed Methods Study

open access: yesArthritis Care &Research, Accepted Article.
Objective To evaluate utility of an artificial intelligence (AI) health coach for systemic sclerosis (SSc) self‐management and identify patterns associated with participant engagement. Methods We conducted a mixed‐methods study in which an AI health coach, powered by a large language model (LLM), was used to support self‐management for SSc.
Nirali Shah   +4 more
wiley   +1 more source

A Lightweight Procedural Layer for Hybrid Experimental–Computational Workflows in Materials Science

open access: yesAdvanced Engineering Materials, EarlyView.
We unveil a prototype hybrid‐workflow framework that fuses automatedcomputation with hands‐on experiments. Built atop pyiron, a lightweight, parameterized layer translates procedure descriptions into executable manual steps, syncing instrument settings, human interventions, and data capture in real‐time today.
Steffen Brinckmann   +8 more
wiley   +1 more source

Toward Knowledge‐Based Workflows: A Semantic Approach to Atomistic Simulations for Mechanical and Thermodynamic Properties

open access: yesAdvanced Engineering Materials, EarlyView.
Knowledge‐based atomistic workflows are presented for mechanical and thermodynamic properties. By coupling modular simulations with ontology‐aligned metadata and provenance, Fe case studies on elastic behavior, defects, thermal properties, and Hall–Petch strengthening reveal how FAIR, queryable, and reusable simulation data can be generated. Mechanical
Abril Azócar Guzmán   +5 more
wiley   +1 more source

Teacher-Student-Relationship Quality in Inclusive Secondary Schools: Theory and Measurement of Emotional Aspects of Teaching

open access: yesFrontiers in Education, 2021
Inclusive healthy schools are committed to provide a learning environment for a healthy development and optimal learning support for all students, regardless of their performance, language, learning and behavior disposition or disability.
Giuliana Pastore, Reto Luder
doaj   +1 more source

On Computational Mechanisms for Shared Intentionality, and Speculation on Rationality and Consciousness

open access: yesCoRR, 2023
This paper builds on our earlier arXiv:2209.03956 and provides the background for our arXiv:2207 ...
openaire   +2 more sources

Low Cycle Repetitive Loading of Ti‐6Al‐4V‐Epoxy Composite Lattice Structures for Enhanced Energy Dissipation and Damage Tolerance

open access: yesAdvanced Engineering Materials, EarlyView.
Composite Ti–6Al–4V–epoxy lattice structures are additively manufactured and epoxy infiltrated for cyclic loading. At low lattice volume fractions, hybridization produces synergistic gains in stiffness and energy dissipation. At higher volume fractions, synergy diminishes, although composites still exceed metallic lattices in specific energy ...
Joey Tallon   +3 more
wiley   +1 more source

Analysis of the cognitive processes involved in creating and sustaining cooperative group activity

open access: yesFrontiers in Psychology, 2022
A cooperative group activity (CGA) and shared intentionality are two phenomena whereby two or more individuals engage in an activity with the intention that the group will succeed, that is, to act as a “we.
Simon Skau, Simon Skau
doaj   +1 more source

Home - About - Disclaimer - Privacy