Results 141 to 150 of about 18,489,894 (342)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Beyond Kuhn: Methodological Contextualism and Partial Paradigms [PDF]
, 2018 Kuhn’s view of science is as follows. Science involves two key phases: normal and extraordinary. In normal science, disciplinary matrices (DMs) are large and pervasive.
Rowbottom, Darrell P.
core
Molecular Oncology, EarlyView.Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor +2 more
wiley +1 more source
, 2023 Focusing solely on short-term profits has caused social, environmental, and economic problems. Creating shared value integrates profitability with social and environmental objectives, offering a holistic solution. This dissertation examines two areas where this integration is crucial.
openaire +1 more source
India and Pakistan: Trading for Peace [PDF]
Are shared democratic values the most important factors in promoting peace between countries, or common economic interests? New econometric research shows that, in the case of India and Pakistan, trade with other countries increases the chance of peace ...
Mamoon, Dawood, S. Murshed, Mansoob
core +1 more source
"Two bedrooms, two toothbrushes" : a qualitative study of shared care parenting : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Psychology at Massey University, Wellington, New Zealand [PDF]
, 2015 Shared care is a post-separation family living arrangement whereby the children move between the parents living in two separate houses. This custody arrangement has grown more popular in the last few decades, although little is known about a young ...
Merson, Tracy Ellen
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Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source