Results 161 to 170 of about 21,773 (245)

A Pharmacometric Method for Quantitative Determination of Improvement in Body Composition and Characterization of the Exposure–Response Relationship during Treatment of Obesity with Tirzepatide

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
About half of the world's population is living with overweight or obesity. Tirzepatide is an approved treatment for chronic weight management. We sought to characterize the exposure–response relationship for weight reduction in patients with overweight or obesity and quantify the associated changes in body composition.
Emmanuel Chigutsa   +4 more
wiley   +1 more source

Population Pharmacokinetics and Exposure‐Response Analysis of First‐Line Osimertinib Plus Chemotherapy in Patients with EGFR‐Mutated Advanced NSCLC

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Osimertinib, a third‐generation, central nervous system‐active epidermal growth factor receptor‐tyrosine kinase inhibitor, potently and selectively inhibits epidermal growth factor receptor‐tyrosine kinase inhibitor sensitizing and T790M resistance mutations, with efficacy in epidermal growth factor receptor‐mutated non‐small cell lung cancer.
Jincheng Yang   +10 more
wiley   +1 more source

Staggered Board and Sexually Diverse Policies Adoption: Benevolence Motivation or Deeper Entrenchment?

open access: yesCorporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Building sexually diverse workplaces has become increasingly crucial for corporates. To create sexually diverse workplaces, firms require a high level of commitment collectively from their stakeholders, especially from corporate leadership.
Nuttavuth Nundhapana   +2 more
wiley   +1 more source

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