Results 161 to 170 of about 24,481 (283)

Use of PopPK and E‐R Analyses toward Explaining Causal Link Between ADAMTS13 in Recombinant vs. Plasma‐Based Therapies and Clinical Effects in cTTP

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Congenital thrombotic thrombocytopenic purpura (cTTP) is an ultra‐rare, potentially life‐threatening condition caused by a deficiency of the blood enzyme ADAMTS13. Until now, ADAMTS13 replacement has been achieved with infusions of plasma or plasma‐based therapies (PBT).
Munjal Patel   +11 more
wiley   +1 more source

Exposure‐Response Relationships for Axatilimab in Patients with Chronic Graft‐Versus‐Host Disease

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Axatilimab, a high‐affinity humanized monoclonal antibody that targets colony‐stimulating factor 1 receptor, is approved for the treatment of chronic graft‐versus‐host disease (cGVHD). Here, we describe the exposure‐response relationships for efficacy and safety in patients with cGVHD who received axatilimab.
Yan‐ou Yang   +7 more
wiley   +1 more source

The Business Case for Circular Economy: A Co‐Evolutionary Perspective for Integrating Moral Cases Into Circular Economy Business Cases

open access: yesCorporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT The ongoing debate in corporate sustainability (CS) about the moral case versus the business case has recently made its way into the circular economy (CE) discourse, bringing with it new tradeoffs. Although the business case perspective emphasizes profitability, critics argue that the moral case must go beyond profit motives and include ...
Felix Carl Schultz   +2 more
wiley   +1 more source

A Meta Analytical Study of Cultural Conditions Moderating the Relationship Between Board Diversity and CSR Disclosure

open access: yesCorporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Studies on the relationship between board diversity and CSR disclosure have shown mixed results. This study investigates the relationship between board diversity attributes and CSR disclosure, as well as the various cultural conditions influencing board diversity–CSR disclosure relationships through meta‐analysis based on data from 45 ...
Waris Ali   +2 more
wiley   +1 more source

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