Results 261 to 270 of about 483,611 (352)

Predicting Danish EQ-5D-5L Utilities Based on United Kingdom EQ-5D-3L Utilities for Use in Health Economic Models. [PDF]

open access: yesPharmacoecon Open
Torkilseng EB   +8 more
europepmc   +1 more source

A Phase 1C, Open Label, Single Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of DM199 Administered Intravenously with a Polyvinyl Chloride Bag in Adult Healthy Subjects and Adults Recently Taking Angiotensin‐Converting Enzyme Inhibitors

open access: yesClinical Pharmacology in Drug Development, EarlyView.
Abstract This small phase 1C, open‐label, single ascending dose study evaluated the safety, tolerability, and pharmacokinetics (PKs) of DM199, a recombinant form of human tissue kallikrein‐1 (KLK1). A small sample size of both healthy subjects and hypertensive adults recently taking angiotensin‐converting enzyme inhibitors was studied. KLK1 has a known
Michael Giuffre   +3 more
wiley   +1 more source

Cyclin E1/CDK2 activation defines a key vulnerability to WEE1 kinase inhibition in gynecological cancers. [PDF]

open access: yesNPJ Precis Oncol
Kim D   +28 more
europepmc   +1 more source

Improved Prediction of CYP2D6 Catalyzed Drug Metabolism by Taking Variant Substrate Specificities and Novel Polymorphic Haplotypes into Account

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
The polymorphic CYP2D6 enzyme plays a pivotal role in the metabolism of approximately 25% of clinically prescribed drugs. However, the impact of specific genetic variants on the interindividual variability in CYP2D6‐mediated drug metabolism remains insufficiently quantified. This translational study sought to address this gap by analyzing the genotypes
Inger Johansson   +11 more
wiley   +1 more source

Board Characteristics and Stakeholder Engagement and ESG Performance: The Relevance of European Gender Parity

open access: yesCorporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT The main goal of this study is to explore the effect of country‐level gender parity with a board characteristics and stakeholder engagement on ESG performance in sustainable companies. The sample comprises 940 sustainable international sustainable firm‐year observations from the following 13 countries: Denmark, Finland, France, Germany ...
Alfredo Grau‐Grau   +2 more
wiley   +1 more source

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