Results 211 to 220 of about 362,376 (264)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Urban-Rural Disparities in Geographic Healthcare Accessibility: A Comparative Study of Nigeria and Zambia. [PDF]

open access: yesJ Urban Health
Fang W   +13 more
europepmc   +1 more source

To Share or Not to Share

Annals of Plastic Surgery, 1985
We describe our extensive experience in nipple reconstruction on breasts formed by subpectoral implants, latissimus dorsi musculocutaneous flaps, or rectus abdominis musculocutaneous flaps.
G S, Georgiade   +2 more
openaire   +2 more sources

To Share or Not to Share

ITNOW, 2014
Sharing is an important indicator of internalised prosocial values. We examined predictors of sharing of 302 preschoolers with their younger siblings in a one-year longitudinal study. Sharing was observed during different home visits, once with father and once with mother.
S. R. Van Berkel   +6 more
openaire   +3 more sources

To Share or Not to Share SHARE-it: Lessons Learnt

2011
The purpose of this position paper is to discuss the authors’ reflections on the use of Assistive Technologies to support user’s autonomy to perform the necessary Activities of Daily Living (ADL). In special, we will address the use of Agent-based robotic services.
Roberta Annicchiarico, Ulises Cortés
openaire   +1 more source

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