Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Sunscreen is overwhelmingly promoted on TikTok, but content with misinformation exhibits proportionally high levels of audience interaction. [PDF]
PLOS Digit HealthMarcon A +4 more
europepmc +1 more source
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
The quality and content of cerebral aneurysm related short videos on Douyin: a cross-sectional observational study. [PDF]
Sci RepYang GP, Yang KX, Chai HM.
europepmc +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Evaluation of the quality and reliability of infertility information on Chinese social media platforms Bilibili and TikTok : a cross-sectional study. [PDF]
BMC Public HealthZhang J, He J, Wei Q, Rao M.
europepmc +1 more source
RETRACTION: Dentatin Induces Apoptosis in Prostate Cancer Cells via Bcl-2, Bcl-xL, Survivin Downregulation, Caspase-9, -3/7 Activation, and NF-κB Inhibition. [PDF]
Evid Based Complement Alternat MedAnd Alternative Medicine EC.
europepmc +1 more source
RAF1 scaffold integrity shapes chemogenetic degradation outcomes in KRAS-driven lung cancer models. [PDF]
Life Sci Alliancede-la-Puente-Ovejero L +8 more
europepmc +1 more source
Quality and content evaluation of anal fistula information on TikTok and Bilibili: A cross-sectional study. [PDF]
Medicine (Baltimore)Du X +6 more
europepmc +1 more source