Bioengineered 3D hPSC‐Cholangiocyte Ducts With Physiological Signals for Biliary Disease Modeling
Tian and colleagues generated a bioengineered bile duct from human pluripotent stem cell (hPSC)‐derived intrahepatic cholangiocytes within a high‐throughput, 384‐well platform to systematically examine the influence of biliary physiological signals including fluid flow, stromal cells and bile acids, and models intrahepatic biliary disease progression ...
Britney Tian +10 more
wiley +1 more source
Shear Lag Effect of Ultra-Wide Box Girder under Influence of Shear Deformation
The objective of this study was to determine the reasonable flexural functions of ultra-wide box girders, reveal the mechanism of the shear lag effect, and improve the analysis theory of ultra-wide box girders. Considering a single-box three-chamber thin-
Yanfeng Li +3 more
doaj +1 more source
ON SHEAR LAG IN CONTINUOUS BOX GIRDER
On the basis of the sufficiently accurate approximate solutions obtained by using generalized Galerkin's method, both the stress distribution and the variation of shear lag extending over the total length are investigated with respect to the continuous box girder, having the steel deck.Since it is readily seen that this phenomenon has a general ...
openaire +2 more sources
Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang +4 more
wiley +1 more source
Sensitivity of the Magnetorotational Instability to the shear parameter in stratified simulations
The magnetorotational instability (MRI) is a shear instability and thus its sensitivity to the shear parameter $q = - d\ln\Omega/d\ln r $ is of interest to investigate.
Blackman, Eric G., Nauman, Farrukh
core +1 more source
Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu +4 more
wiley +1 more source
From shear lag to atomic fit [PDF]
Bronsveld, P.M., Hosson, J.Th.M. De
openaire +2 more sources
Microengineered Gradient Hydrogels for Mechanobiology
Gradient hydrogels are used to mimic the mechanical heterogeneity in native tissues, offering powerful in vitro platforms to study cell‐material interactions in diverse pathophysiological contexts. Here, we present a comprehensive review of the design and experimental considerations for stiffness gradient hydrogels, discussing exemplary achievements ...
Shin Wei Chong +4 more
wiley +1 more source
Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy
This review summarizes the developmental basis of endochondral ossification (ECO) and its applications in bone tissue engineering (BTE). It first outlines the key biological processes and signaling pathways underlying ECO, then discusses biomaterial‐based engineering strategies derived from these principles, and finally highlights future directions for
Yiqi Su +8 more
wiley +1 more source
An experimental approach to quantify strain transfer efficiency of fibre bragg grating sensors to host structures [PDF]
This paper developed a method to evaluate the strain transfer efficiency of fibre Bragg grating sensors to host structures. Various coatings were applied to fibre Bragg grating sensors after being fabricated.
Irving, Phil E. +4 more
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