Results 221 to 230 of about 87,948 (310)

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng   +7 more
wiley   +1 more source

High‐Performance Multi‐Walled Carbon Nanotubes‐Organic Passivated Si Solar Cells Enabled by Spatially Selective Harvesting of High‐Quality Sponges

open access: yesAdvanced Science, EarlyView.
Our work achieves an efficiency breakthrough in MWCNTs/Si solar cells by screening high‐quality pristine MWCNTs without any separation or purification processes. This breakthrough is mainly attributed to the excellent dispersibility of Nafion and the excellent hole transport property of MWCNTs:Nafion film containing charge transfer doping, passivation,
Yuke Ren   +13 more
wiley   +1 more source

Polarization Dynamics in Ferroelectrics: Insights Enabled by Machine Learning Molecular Dynamics

open access: yesAdvanced Science, EarlyView.
Machine learning molecular dynamics is presented as a route to capture polarization switching, domain wall kinetics, topological polar textures, and polar mechanical coupling beyond the limits of conventional atomistic methods. This Perspective surveys recent progress and identifies key methodological directions, including long‐range electrostatics ...
Dongyu Bai   +3 more
wiley   +1 more source

Beyond Potency: Emerging Determinants and Optimization Strategies Enhancing Therapeutic Efficacy of Adult Stem Cells

open access: yesAdvanced Science, EarlyView.
Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim   +2 more
wiley   +1 more source

Coupled Electronic and Ionic Conductivity in Strain‐Stiffening Hydrogels

open access: yesAdvanced Science, EarlyView.
A soft PVA–PABA hydrogel is developed that couples tissue‐like strain‐stiffening mechanics with dual ionic–electronic conduction. Dynamic boronic crosslinks enable self‐assembled percolative pathways, producing deformation‐responsive resistance with a stabilization plateau at stiffening onset, revealing alignment‐assisted charge transport and advancing
Md Al Raihan   +6 more
wiley   +1 more source

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