Results 51 to 60 of about 328,048 (333)

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

The internal structure and composition of a plate-boundary-scale serpentinite shear zone: the Livingstone Fault, New Zealand [PDF]

Solid Earth, 2019
Deciphering the internal structure and composition of large serpentinite-dominated shear zones will lead to an improved understanding of the rheology of the lithosphere in a range of tectonic settings.
M. S. Tarling, S. A. F. Smith, J. M. Scott, J. S. Rooney, C. Viti, K. C. Gordon   +5 more
doaj   +1 more source

Preparation and characterization of renal cell peptides from fetal rats for their antitumor activity

FEBS Open Bio, EarlyView.
This study aimed to prepare renal cells (RCs) from fetal rats which were digested by enzymes. Candidate peptides RCPs were characterized by capillary HPLC and MS and their bioactivity was predicted using peptideranker. The predicted top 10 bioactive peptides were synthesized.
Zhe Zhang, Yuan Cao, Jing Du, Ying Zhang, Junxia Wang, Ying Yuan, Lianqing Sun   +6 more
wiley   +1 more source

Modeling of temperature distribution in orthogonal cutting with dual-zone contact at rake face [PDF]

, 2012
In this study, an analytical model is developed in order to calculate the temperature distribution in orthogonal cutting with dual-zone contact at the rake face. The study focuses on heat generation at the primary shear zone and at the rake face.
Bakkal, Mustafa, Budak, Erhan, Cakir, Esin, Ozlu, Emre, Çakır, Esin, Özlü, Emre   +5 more
core   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Zircon dissolution in a ductile shear zone, Monte Rosa granite gneiss, northern Italy [PDF]

, 2008
The sizes, distributions and shapes of zircon grains within variably deformed granite gneiss from the western Alps have been studied. Zircon shows numerous indicators of a metamorphic response in both the host gneiss and a 5 cm wide continuous ductile ...
Dal Piaz, Engi, Ewing, Hanchar, Hunziker, J. C. Martin, Keller, Kretz, Liati, Moller, Pawlig, Rubin, T. J. Dempster, Varva, Z. K. Shipton   +14 more
core   +1 more source

Soft‐Layered Composites with Wrinkling‐Activated Multi‐Linear Elastic Behavior, Stress Mitigation, and Enhanced Strain Energy Storage

Advanced Engineering Materials, EarlyView.
In this study, exciting new bi‐/multi‐linear elastic behavior of soft elastic composites that accompany the activation of wrinkling in the embedded interfacial layers is analyzed. The new features and performance of these composite materials, including dramatic enhancements in energy storage, can be tailored by the concentration of interfacial layers ...
Narges Kaynia, Nicholas Xuanlai Fang, Mary C. Boyce   +2 more
wiley   +1 more source

Thermomechanical modeling of orthogonal cutting including the effect of stick-slide regions on the rake face [PDF]

, 2007
An orthogonal cutting model including the primary and secondary shear zones is pre-sented in this study. The primary shear zone is modeled by a thermomechanical model where the rake contact is represented by two regions of respectively sticking and ...
Budak, Erhan, Molinari, Alain, Özlü, Emre   +2 more
core  

Non‐Destructive and Mechanical Characterization of the Bond Quality of Co‐Extruded Titanium‐Aluminum Profiles

Advanced Engineering Materials, EarlyView.
This study investigates the bond quality of co‐extruded aluminum–titanium hybrid profiles, focusing on the lateral angular co‐extrusion (LACE) process. It examines how heat treatments (HT) affect intermetallic phase formation, bond strength, and material properties.
Norman Mohnfeld, Ahmed Dewidar, Karim Qarbi, Hendrik Wester, Florian Patrick Schäfke, Alexej Verschinin, Hans Jürgen Maier, Sebastian Barton, Christian Klose, Johanna Uhe   +9 more
wiley   +1 more source

K-Ar illite-mica age constraints on the formation and reactivation history of the El Doctor fault zone, central Mexico

Revista Mexicana de Ciencias Geológicas, 2018
The tectonic history of the Mexican Fold and Thrust Belt exposed in the Sierra Madre Oriental can be assessed in detail by dating the activation of the major shortening structures.
Diana Elizabeth Garduño-Martínez, Teresa Pi Puig, Jesús Solé, Michelangelo Martini, Jorge René Alcalá-Martínez   +4 more
doaj   +1 more source