Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
European Metropolitan Regions in Germany – a regional economic evaluation [PDF]
For more than ten years the concept of European Metropolitan Regions is fixed in the German regional planning system. This article uses the shift-share-technique to assess the economic performance of the eleven German metropolitan areas based on a ...
Oberst, Christian, Rusche, Karsten
core +1 more source
Analisis Ekonomi Dan Sektor Unggulan Untuk Pengembangan Halmahera Tengah [PDF]
, 2011 This study is conducted in 2008, is one part of the Spatial Planning of CentralHalmahera years 2009-2019. The analytical method used is the shift share and the location quotient.
djarwadi, D. (djarwadi) +1 more
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
An Examination of the Geography of Population Composition and Change in the United States, 2000-2010: Insights from Geographical Indices and a Shift-Share Analysis. [PDF]
Popul Space Place, 2014 Franklin RS.
europepmc +1 more source
Transformasi Struktur Ekonomi dan Sektor Unggulan di Kabupaten Buleleng Periode 2008-2013 [PDF]
, 2016 The impact of development of a region, such as the changes in what sectors increases or decreases, the knowledge of which is important in the development of a region.
Suyana Utama, I Made +1 more
core
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
The Impact of Transition and Economic Integration on Manufacturing Employment Change: An Assessment for the Regions of the European Union New Member-States. [PDF]
The spatial and structural dynamics generated (or released) in the contexts of the parallel and interacting processes of transition and economic integration have already left a clear mark in the economic landscape of the EU new member-states.
Dimitrios Kallioras
core
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source