Results 71 to 80 of about 44,629 (263)
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Unnes Journal of Public Health, 2015 The purpose of this research is to determine the relationship between work shift and subjective fatigue of work at internet cafe operators in Sekaran. Shift work can affect variety of physical and psychological changes in the people including fatigue ...
. Muvarichin
doaj +1 more source
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
On the Complete Indeterminacy and the Chaoticity of the Generalized Heun Operator in Bargmann Space
AxiomsIn 1998, we gave a complete scattering analysis of the cubic Heun operator H=a∗(a+a∗)a acting on Bargmann space, where a and a∗ are the standard Bose annihilation and creation operators satisfying the commutation relation [a,a∗]=I.
Abdelkader Intissar
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Resonance and differential reduction of Feynman integrals
Journal of High Energy PhysicsFeynman integrals may be viewed as generalized hypergeometric functions, and specifically as solutions of GKZ systems of partial differential equations that typically exhibit resonance.
Ruth Britto +2 more
doaj +1 more source
Nabla derivatives associated with nonlinear control systems on homogeneous time scales
Nonlinear Analysis, 2016 The backward shift and nabla derivative operators, defined by the control system on homogeneous time scale, in vector spaces of one-forms and vector fields are introduced and some of their properties are proven.
Zbigniew Bartosiewicz +5 more
doaj +1 more source