Results 91 to 100 of about 314,239 (265)

MUDANÇAS NA PRODUÇÃO AGRÍCOLA DA REGIÃO SUL DO BRASIL

Estudo & Debate
O trabalho analisou como ocorreram as mudanças na produção agrícola das culturas temporárias de verão, na região Sul do Brasil, entre os anos de 1990 e 2020.
Ronaldo Torres, Reisoli Bender Filho
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

DAYA SAING PRODUK EKSPOR DI ERA PERDAGANGAN BEBAS

Jurnal Ekonomi & Studi Pembangunan, 2012
: Efforts to improve the competitiveness of export products industry is one of the challenges faced by the Province of Yogyakarta in the era of trade liberalization.
Sri Suharsih, Asih Sriwinarti
doaj  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

LA IDENTIDAD MAGALLÁNICA DADOS LOS PRINCIPALES CAMBIOS ECONÓMICOS Y ESTRUCTURALES OCURRIDOS EN CHILE ENTRE 1960 Y 2008 MAGELIAN IDENTITY GIVEN THE PRINCIPAL ECONOMIC AND STRUCTURAL CHANGES OCURRED IN CHILE BETWEEN 1960 AND 2008

Magallania, 2010
El presente trabajo1-2consiste en identificar a la o las actividades económicas que han contribuido al desarrollo de la región de Magallanes, para ello se recurre a dos variables, al Producto Interno Bruto Regionalizado (PIBr) y Empleo por Rama de ...
SERGIO SOZA-AMIGO
doaj  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Efeito da área e da produtividade na produção de celulose no Brasil Effect of area and productivity in pulp production in Brazil

Revista Árvore, 2012
O presente trabalho teve por objetivo estudar a evolução tecnológica da produção de madeira para celulose, para tanto, a produção de celulose de fibra curta derivada do eucalipto foi decomposta em efeito área e efeito produtividade. Para isso foi usado o
Kaio Henrique Adame de Carvalho, Márcio Lopes da Silva, Naisy Silva Soares   +2 more
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Analysis of the agricultural productivity of the sugarcane crop in regions of new agricultural expansions of sugarcane

Gestão & Produção
The launching of biofuel vehicles in 2003 led to ethanol demand increase and a new phase of expansion of sugarcane cultivation in Brazil. Although the increase in area of production and the quantity of sugarcane produced have been very important to ...
Roberto Bernardo, Wagner Luiz Lourenzani, Eduardo Guilherme Satolo, Marcellus Marques Caldas   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source