Results 221 to 230 of about 3,389,884 (311)

Strengthening HIV Programs in Sub-Saharan Africa Through Implementation Research: A Mixed-Methods Systematic Review. [PDF]

AIDS Res Treat
Bwire GM, Nyondo GG, Njiro BJ, Aiko BG, Mikomangwa WP, Manguzu MA, August F, Myemba DT, Magati R, Chillo P, Mugusi F, Bakari M, Sudfeld C, Sangeda RZ, Killewo J.   +14 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Emotion regulation variability and flexibility in daily life show distinct associations with well-being, age, and executive functions. [PDF]

Sci Rep
de la Fuente D, Karbach J, Basten U, Glombiewski JA, In-Albon T, Lischetzke T, Mema C, Rammensee RA, Schmitt MC, Könen T.   +9 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities". [PDF]

Alzheimers Dement
Baez S.
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Sustained increases in life expectancy and changes in lifespan variation in South Korea, 1970-2023: decomposing compression and shifting of mortality. [PDF]

Popul Health Metr
Kim I, Jeon J, Kim C, Bae H, Son MS.
europepmc   +1 more source

Task shifting from physicians to nurses in primary care in 39 countries: a cross-country comparative study.

European Journal of Public Health, 2016
C. Maier, L. Aiken
semanticscholar   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Reply to Erren et al. and Martin-Olalla and Mira: What constitutes circadian burden? An empirically grounded approach to long-term summary metrics. [PDF]

Proc Natl Acad Sci U S A
Weed L, Zeitzer JM.
europepmc   +1 more source