Results 91 to 100 of about 3,212,380 (290)

Medication Error During the Day and Night Shift on Weekdays and Weekends: A Single Teaching Hospital Experience in Riyadh, Saudi Arabia

open access: yesRisk Management and Healthcare Policy, 2021
Mohammed Aljuaid,1 Najla Alajman,2 Afraa Alsafadi,3 Farrah Alnajjar,4 Mashael Alshaikh3 1Department of Health Administration, College of Business Administration, King Saud University, Riyadh, Saudi Arabia; 2Department of Rehabilitation, Sultan Bin ...
Aljuaid M   +4 more
doaj  

Einstein Shift and Doppler Shift [PDF]

open access: yesNature, 1926
IN answer to Sir Oliver Lodge's question (NATURE, December 26, p. 938), it depends on our point of view whether the Einstein shift is considered to be imposed on the light at its origin or in course of transit to us. We cannot state the frequency of the ether vibrations without presupposing a system of time-reckoning, and in the non-Euclidean region ...
openaire   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Um estudo teórico de parâmetros estruturais e vibracionais de sistemas intermoleculares formados por interações H∙∙∙H e H∙∙∙F nos sistemas NaH∙∙∙2HF e NaH∙∙∙4HF

open access: yesOrbital: The Electronic Journal of Chemistry, 2014
No presente trabalho foi estudado os complexos fortemente ligados NaH∙∙∙2HF e NaH∙∙∙4HF formados por ligações de di-hidrogênio H∙∙∙H e ligações de hidrogênio F∙∙∙H com o objetivo de estudar parâmetros estruturais e vibracionais.
D. G. Rego   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

An objective criticism of the Persian translation of Dickens' Hard times according to Broeck's systemic model of trancism

open access: yesSocial Sciences and Humanities Open
A critique of the translation should be conducted using a systematic model, free from any subjective biases. In this study, an objective assessment was made of the Persian translation of Dickens (1985) Hard Times according to a systematic model of ...
Hamidreza Abdi
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Translation Shifts in Gibran’s The Prophet

open access: yesمجلة العلوم التربوية والدراسات الإنسانية سلسلة الآداب والعلوم التربوية والإنسانية والتطبيقية
This research paper aimed at investigating translation shifts in two Arabic translations of Gibran’s The Prophet, using Leuven-Zwart’s comparative and descriptive model.
Abdul-Kawi Hizam M. al-Shamiri   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

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