Results 201 to 210 of about 1,036,191 (291)

NUAK2 Inhibition Enhances Macromolecular Drug Delivery in a 3D Fibrotic Model of the Pancreatic Tumor Microenvironment

Advanced NanoBiomed Research, EarlyView.
Using a 3D cell culture model of the fibrotic barrier in pancreatic cancer, this work shows that inhibiting NUAK2 kinase in pancreatic stellate cells enhances macromolecular drug delivery. Mechanistically, NUAK2 inhibition disrupted actin stress fiber assembly to downregulate collagen I expression, thus enhancing macromolecular permeability.
Misaki Nakamura, Hiroyoshi Y. Tanaka, Mayu Ohira, Haruko Ohta‐Okano, Reika Nakamura, Yu Seno, Saaya Yara, Sakura Fujita, Daichi Shibata, Masaya Yamamoto, Shinichi Toyooka, Kensuke Osada, Horacio Cabral, Atsushi Masamune, Mitsunobu R. Kano   +14 more
wiley   +1 more source

Fereydoun Hoveyda: The Broken Crescent Study Guide [PDF]

, 2003
Samson, Steven Alan
core  

Energy‐Efficient and Sustainable Design Optimization for Ternary Mixture Separation: A Comparative Analysis of Sequential Iterative Optimization and Non‐Dominated Sorting Genetic Algorithm II

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT This study presents a comparative analysis of two optimization approaches: Sequential Iterative Optimization (SIO) and Non‐dominated Sorting Genetic Algorithm II (NSGA‐II) applied to the separation of ternary mixtures (1‐butanol, isobutanol, and 2‐butanol) using Dual‐Column Distillation (DCD) and Dividing‐Wall Column (DWC) processes. Through a
Ruijie Wang, Xinlan Weng, Xiaoxin Gao, Zhimeng Wang, Xiaoyu Kang, Zeyang Li   +5 more
wiley   +1 more source

Study on Natural Gas Decarbonization Process Based on CO2 Desublimation Characteristics

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Natural gas decarbonization is a crucial processing step. In this study, the snow separation technology for removal of carbon dioxide in natural gas based on CO2 desublimation characteristics was introduced. The phase equilibrium calculation of CH4‐CO2 and N2‐CO2 system was carried out by using cubic equations of states (EOSs), and identified ...
Haiqin Wang, Jushi Cai, Zubin Zhang, Qishen Wu   +3 more
wiley   +1 more source

Design of Experiments‐Based Optimization of Recovered Carbon Black–Reinforced Isobutylene–Isoprene Rubber in Comparison With Conventional Carbon Black Systems

Journal of Applied Polymer Science, EarlyView.
Optimized potential of rCB via DOE: recovered carbon black from end‐of‐life tires was assessed as a full substitute for conventional carbon black in IIR composites. DOE and response surface methodology optimized rCB loading, plasticizer, and sulfur contents. Hardness showed linear trends, while rupture energy was nonlinear.
Vinícius Guedes Gobbi, Ester Costa de Almeida, Roberta Helena Mendonça, Marysilvia Ferreira da Costa   +3 more
wiley   +1 more source

Recent Advances in Stimulated Brillouin Scattering in Integrated Photonics

Advanced Physics Research, EarlyView.
This review systematically surveys recent advances in stimulated Brillouin scattering (SBS) within integrated photonics. It begins by elucidating the fundamental mechanisms of stimulated coupling between photons and acoustic phonons in nanoscale waveguides, enhanced by the photoelastic and moving boundary effects.
Songyue Liu, Qi Lu, Pan Hu, Yuan Zhong, Yu He, Yaojing Zhang, Young‐Ik Sohn, Yikai Su, Lu Sun   +8 more
wiley   +1 more source

Peter Adamson, Richard C. Taylor, The Cambridge Companion to Arabic Philosophy [PDF]

, 2005
Marcotte, Roxanne D.
core  

Drivers of tail evolution in squamates and their implications for the fossorial origin of snakes

The Anatomical Record, EarlyView.
Abstract The axial skeleton serves as the primary structural support in all vertebrates and is subdivided into five distinct regions: cervical, thoracic, lumbar, sacral, and caudal. Relaxation of constraints acting on the terminal end of the axial skeleton has led to remarkable variation in caudal vertebrae number across Squamata.
Olivia Binfield, Marco Camaiti, Lucy Roberts   +2 more
wiley   +1 more source

Editorial Commentary: Evidence Remains Elusive Regarding the Causal Effect of Delayed Posterior Cruciate Ligament Reconstruction on Intra‐articular Injury Incidence Due to Persistent Knee Instability

Arthroscopy, EarlyView.
Abstract Determining the optimal surgical timing for isolated posterior cruciate ligament (PCL) reconstruction remains challenging, particularly regarding the relationship between persistent instability and secondary intra‐articular pathology. Establishing causality between delayed reconstruction and intra‐articular injury prevalence is difficult due ...
Bálint Zsidai, Eric Hamrin Senorski, Volker Musahl, Kristian Samuelsson   +3 more
wiley   +1 more source