Results 1 to 10 of about 7,326 (212)
PH responsive hydrogel nanocomposites for targeted Shikonin delivery enhance anti PDL1 immunotherapy in osteosarcoma [PDF]
Discover OncologyObjective To enhance the therapeutic effect of atezolizumab on osteosarcoma (OS) by constructing a pH-responsive hydrogel nanocomplex (Gel@PLGA@FA) as a delivery platform for Shikonin.
Xiang-yi Chen +2 more
doaj +2 more sources
Shikonin inhibits epithelial-mesenchymal transition in glioblastoma cells by upregulating p53 and promoting miR-361-5p level to suppress ZEB1 expression [PDF]
BMC NeuroscienceObjective Shikonin, an active compound from the rhizome of Lithospermum erythrorhizon, exerts anti-tumor effects in various cancers, including glioblastoma multiforme (GBM).
Fengying Zhang +7 more
doaj +2 more sources
Exploring the Mechanism of Oral Cancer With Shikonin Based on the Network Pharmacology and Molecular Docking Technology [PDF]
International Dental JournalObjectives: To explore the underlying mechanisms of shikonin in treating oral cancer using network pharmacology and molecular docking methods. Materials and methods: Targets of shikonin were obtained from the TCMSP, BATMAN, ChEMBL, PharmMapper and HERB ...
Lin Hou +5 more
doaj +2 more sources
Antioxidants, 2021 Shikonin mitigated tumor cell proliferation by elevating reactive oxygen species (ROS) levels. Herein, we investigated the effects of shikonin on renal cancer cell (RCC) cell proliferation.
Ming-Feng Tsai +7 more
doaj +1 more source
Molecules, 2022 Shikonin is the main component of root extracts from the Chinese herbal medicine Lithospermum erythrorhizon, which is commonly used for the treatment of various diseases including cancer.
Wenjing Ji +8 more
doaj +1 more source
Pharmacological Effects of Shikonin and Its Potential in Skin Repair: A Review
Molecules, 2023 Currently, skin injuries have a serious impact on people’s lives and socio-economic stress. Shikonin, a naphthoquinone compound derived from the root of the traditional Chinese medicine Shikonin, has favorable biological activities such as anti ...
Yanping Song +5 more
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Shikonin Inhibits Cancer Through P21 Upregulation and Apoptosis Induction
Frontiers in Pharmacology, 2020 Shikonin is a natural naphthoquinone compound and has demonstrated potent anti-cancer activities; however, the underlying molecular mechanisms remained elusive. Here we report that Shikonin inhibited the growth of a wide range of human cancer cell lines,
Fangfang Wang +10 more
doaj +1 more source
Control of Foodborne Staphylococcus aureus by Shikonin, a Natural Extract
Foods, 2021 Foodborne Staphylococcus aureus (S. aureus) has attracted widespread attention due to its foodborne infection and food poisoning in human. Shikonin exhibits antibacterial activity against a variety of microorganisms, but there are few studies on its ...
Yangli Wan +7 more
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Shikonin Inhibits Non-Small-Cell Lung Cancer H1299 Cell Growth through Survivin Signaling Pathway
Analytical Cellular Pathology, 2021 Overexpressed survivin is associated with worse survival of several types of human tumors. In this study, the antitumor activity of shikonin in non-small-cell lung cancer (NSCLC) by regulating survivin pathway was investigated.
Haini Wang, Junli Zuo
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Chinese Medicine, 2021 Background Rheumatoid arthritis is a progressive and systemic autoimmune disease seriously compromises human health. Fibroblast like synoviocytes are the major effectors of proliferation and inflammation in rheumatoid arthritis synovial tissue.
Lianhua He +9 more
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