Results 91 to 100 of about 7,326 (212)
Molecular Medicine, 2020 Background The development of paclitaxel-resistance led to the tumor relapse and treatment failure of non-small cell lung cancer. Shikonin has been demonstrated to show anti-cancer activity in many cancer types. The present study aimed to investigate the
Farong Zang +4 more
doaj +1 more source
A reliable protocol for the stable transformation of non-embryogenic cells cultures of grapevine (Vitis vinifera L.) and Taxus x media [PDF]
, 2015 One of the major intent of metabolic engineering in cell culture systems is to increase yields of secondary metabolites. Efficient transformation methods are a priority to successfully apply metabolic engineering to cell cultures of plants that produce ...
Bru-Martinez, Roque +7 more
core +4 more sources
Mechanisms, impacts and therapeutic strategies of glucose metabolic reprogramming in tumours
Clinical and Translational Discovery, Volume 5, Issue 6, December 2025.Tumour metabolic reprogramming initiates a vicious cycle of immunosuppression and therapy resistance. This synergy disarms immunity and fortifies tumour cells, ultimately driving clonal evolution of resistant disease. Abstract Background Glucose metabolic reprogramming is a hallmark of cancer, best exemplified by the Warburg effect.
Li Ma +4 more
wiley +1 more source
Chinese Medical Journal, 2015 Background: Shikonin is a major active chemical component extracted from Lithospermi Radix, an effective traditional herb in various types of wound healing. Shikonin can accelerate granulomatous tissue formation by the rat cotton pellet method and induce
Yan Yan +8 more
doaj +1 more source
Frontiers in PharmacologyOsteosarcoma (OS) is a prevalent primary malignant bone tumor which lacks effective therapeutic interventions. Ferroptosis is a new form of programmed cell death characterized by iron-dependent accumulation of lethal lipid oxidation, which provides a ...
Rui Huang +5 more
doaj +1 more source
Hosting the plant cells in vitro : recent trends in bioreactors [PDF]
, 2013 Biotechnological production of high-value metabolites and therapeutic proteins by plant in vitro systems has been considered as an attractive alternative of classical technologies.
Eibl-Schindler, Regine +2 more
core +1 more source
Analytical Cellular PathologyShikonin is a plant medicine extracted from Lithospermum, which dominate influential antioxidant and antitumor effect. Here, we report that shikonin was capable of inducing human esophageal cancer EC9706 cell apoptosis and autophagy, in a time- and dose ...
Junli Zhang +8 more
doaj +1 more source
Applied SciencesShikonin is a naturally occurring compound known for its anti-inflammatory properties and wound-healing effects. The increased production of reactive oxygen species (ROS) causes oxidative stress and influences the progression of periodontal disease.
Chihiro Fumimoto +7 more
doaj +1 more source
Shikonin inhibits invasiveness of osteosarcoma through MMP13 suppression
Tumor Biology, 2015 Osteosarcoma (OS) is the most common primary malignant bone tumor, notorious for its metastasis. We have recently shown that shikonin, an effective constituent extracted from Chinese medicinal herb, induces necroptosis in OS cells. Nevertheless, the effects of low-dose shikonin on the invasiveness of OS cells are unknown.
Biyong, Deng, Bing, Qiu
openaire +2 more sources
Poststroke Depression as a Factor Adversely Affecting the Level of Oxidative Damage to Plasma Proteins during a Brain Stroke [PDF]
, 2015 Poststroke depression, the second most serious psychosomatic complication after brain stroke, leads to delay of the rehabilitation process and is associated with an increased disability and cognitive impairment along with increase in termmortality ...
Bijak, Michal +4 more
core +2 more sources