Results 101 to 110 of about 7,326 (212)

Spatial distribution of multiple sclerosis disease [PDF]

, 2013
زمینه و هدف: مالتیپل اسکلروزیس (MS) یک بیماری نورولوژیکی مزمن سیستم اعصاب مرکزی می باشد که بوسیله التهاب، تخریب میلین و آسیب اکسونی مشخص می شود. هدف از این تحقیق تعیین کلی شیوع مکانی-فضایی این بیماری در استان چهار محال و بختیاری می باشد.
Baiat, A., Karami, Javad., Katorani, Sh., Mobasheri, Mahmoud., raiesi, R., Ramezannezhad, P., Sarkaregar-Ardakani, A.   +6 more
core  

Shikonin alleviates doxorubicin-induced cardiotoxicity via Mst1/Nrf2 pathway in mice

Scientific Reports
Doxorubicin (DOX) is a popular and potent anticancer drug, but its cardiotoxicity limits its clinical application. Shikonin has a wide range of biological functions, including antioxidant and anti-inflammatory effects.
Hu Tuo, Wenjing Li, Wei Zhao, Juan Zhao, Danni Li, Lin Jin   +5 more
doaj   +1 more source

Shikonin from Echium lycopsis [PDF]

Chemistry of Natural Compounds, 1974
L. R. Shcherbanovskii, Yu. A. Luks
openaire   +1 more source

p53-Mediated Cell Cycle Arrest and Apoptosis Induced by Shikonin via a Caspase-9-Dependent Mechanism in Human Malignant Melanoma A375-S2 Cells

Journal of Pharmacological Sciences, 2004
Natural products regulate cell growth in response to oncogene activation that induces cell cycle arrest and apoptosis in tumor cell lines. We investigated the mechanisms of caspase activation in human malignant melanoma, A375-S2 cells, by the natural ...
Zhen Wu, Lijun Wu, Linhao Li, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima   +5 more
doaj   +1 more source

Negative performance of root extract of Onosma dichroanthum Boiss. on the burn wound healing in an animal model

, 2011
Background: Onosma dichroanthum Boiss. belongs to the Boraginaceae family which locally known as" Hava Chobeh", and it is considered as one of the most important Mountainous medicinal plants in North of Iran, Its red roots have been used by the rural ...
Ghaemi, E.A., Mansourian, A.R., Mazandarani, M., Moghaddam, P.Z., Taheri, S.A., Zolfaghari, M.R.   +5 more
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Transcriptome analysis explores genes related to shikonin biosynthesis in Lithospermeae plants and provides insights into Boraginales’ evolutionary history

Scientific Reports, 2017
Shikonin and its derivatives extracted from Lithospermeae plants’ red roots have current applications in food and pharmaceutical industries. Previous studies have cloned some genes related to shikonin biosynthesis. However, most genes related to shikonin
Feng-Yao Wu, Cheng-Yi Tang, Yu-Min Guo, Zhuo-Wu Bian, Jiang-Yan Fu, Gui-Hua Lu, Jin-Liang Qi, Yan-Jun Pang, Yong-Hua Yang   +8 more
doaj   +1 more source

Shikonin from lithospermum erythrorhizon induces pyroptosis in trophoblast cells by activating the CTSB-NLRP3 inflammasome

Annals of Medicine
Background With the decline of global fertility, drug therapeutic of ectopic pregnancy is of great significance. Lithospermum erythrorhizon is using for embryo killing as herbal medicine.
Fuling Zeng, Yuling Lai, Yanxi Huang, Fangfang Zhu, Jie Gao, Zhenyue Chen, Lihua Zeng, Min Feng, Pin Qiu, Shuo Yuan, Gaopi Deng   +10 more
doaj   +1 more source

Produksi Pigmen Hijau dalam Kultur Suspensi Sel Sauropus androgynus [PDF]

, 2015
Daun katuk (Sauropus androgynus) terkenal di masyarakat sebagai pewarna pangan karena memiliki kandungan klorofil yang tinggi dibandingkan tanaman lain.
Yunita, Oeke
core  

Shikonin Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis to Attenuate Renal Ischemia/Reperfusion Injury by Activating the Sirt1/Nrf2/HO-1 Pathway

Kidney & Blood Pressure Research
Introduction: Shikonin is the major bioactive compound abundant in Lithospermum erythrorhizon and possesses diverse pharmacological properties. This study aimed to examine shikonin roles in experimental renal ischemia/reperfusion (I/R) injury.
Qian Huang, Zilu Shi, Dandan Zheng, Huiqin Chen, Qiuhong Huang   +4 more
doaj   +1 more source

Pharmacological Significance of Boraginaceae with Special Insights into Shikonin and Its Potential in the Food Industry

Foods
Shikonin is a naphthoquinone pigment present in the hairy roots of the plant species from the Boraginaceae family. The compound has been well investigated for its highly efficient medicinal, antioxidant, and antimicrobial properties.
Shweta Gautam, Lubomír Lapčík, Barbora Lapčíková   +2 more
doaj   +1 more source