Results 181 to 190 of about 7,326 (212)

ChemInform Abstract: Cinnamoyl Shikonin.

ChemInform, 2002
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Sanjay Sarkhel, Shefali Shefali, Vijayvitthal T. Mathad, Kanwal Raj, Amiya P. Bhaduri, Prakas R. Maulik, Charlotte K. Broder, Judith A. K. Howard   +7 more
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Assessment of shikonin and acetyl-shikonin for mitigating quorum sensing potential of C. violaceum

Plant Growth Regulation, 2021
Shikonins (SK) and acetyl-shikonins (acetyl-SK) are known to possess great pharmaceutical potentials however, their ability to disrupt infectious bacterial communication system viz. quorum sensing (QS) remains unexplored. Therefore, the rationale behind this research was to investigate the QS-quenching potential of SK and acetyl-SK against C. violaceum
Aliya Fazal, Minkai Yang, Mingyue Wang, Farman Ali, Zhongling Wen, Tongming Yin, Xiangxiang Zhao, Xiaomei Hua, Hongwei Han, Hongyan Lin, Xiaoming Wang, Guihua Lu, Jinliang Qi, Yonghua Yang   +13 more
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Cellular pharmacology studies of shikonin derivatives

Phytotherapy Research, 2002
AbstractThe naphthoquinone pigment, shikonin, isolated from Lithospermum erythrorhizon Sieb. et Zucc.(Boraginaceae) and its derivatives are the active components isolated from the Chinese herbal therapeutic, Zicao. Historically, Zicao root extracts have been used to treat macular eruption, measles, sore‐throat, carbuncles and burns.
Xin, Chen, Lu, Yang, Joost J, Oppenheim, M Zack, Howard   +3 more
openaire   +2 more sources

Natural shikonin and acetyl-shikonin improve intestinal microbial and protein composition to alleviate colitis-associated colorectal cancer

International Immunopharmacology, 2022
Colorectal cancer (CRC) and inflammatory bowel disease (IBD) are the most common diseases of human digestive system. Nowadays, the influence of the inflammatory microenvironment on tumorigenesis has become a new direction, and the exploration of relative molecular mechanism will facilitate the discovery and identification of novel potential anti-cancer
Hongyan, Lin, Xiaopeng, Ma, Xiaorong, Yang, Qingqing, Chen, Zhongling, Wen, Minkai, Yang, Jiangyan, Fu, Tongming, Yin, Guihua, Lu, Jinliang, Qi, Hongwei, Han, Yonghua, Yang   +11 more
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Synthesis of Shikonin and Alkannin

Liebigs Annalen der Chemie, 1991
AbstractThe enantiomeric naturally occurring naphthoquinones shikonin [(R)‐1] and alkannin [(S)‐1] have been synthesized in a thirteen‐step procedure in 44 to 65% e.e. The stereogenic centers of (R)‐1 and (S) are created by the reaction of naphthaldehyde 3 with (R)‐ and (S)‐2‐hydroxy‐1,2,2‐triphenylethyl acetate (2), respectively.
Manfred Braun, Claus Bauer
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Studies onin vitro metabolism of shikonin

Phytotherapy Research, 1999
Shikonin is one of the active components isolated from the root of Arnebia euchrona (Royle) Johnst. It has been shown to possess significant antibacterial, antiinflammatory and antitumour activities and has been used clinically. In this paper, rat liver microsomes were incubated in vitro to study the metabolism of shikonin and a reverse-phase high ...
H, Li, S, Luo, T, Zhou
openaire   +2 more sources

Shikonin and its derivatives: a patent review

Expert Opinion on Therapeutic Patents, 2012
Shikonin and its derivatives are the main components of red pigment extracts from Lithospermum erythrorhizon, whose medicinal properties have been confirmed for a long history, and have aroused great interest as the hallmark molecules responsible for their significant biological activities, especially for their striking anticancer effects.Areas covered
Rubing, Wang, Runting, Yin, Wen, Zhou, Defeng, Xu, Shaoshun, Li   +4 more
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Shikonin derivatives for cancer prevention and therapy

Cancer Letters, 2019
Phytochemicals gained considerable interest during the past years as source to develop new treatment options for chemoprevention and cancer therapy. Motivated by the fact that a majority of established anticancer drugs are derived in one way or another from natural resources, we focused on shikonin, a naphthoquinone with high potentials to be further ...
Joelle C. Boulos, Muhammad Rahama, Mohamed-Elamir F. Hegazy, Thomas Efferth   +3 more
openaire   +2 more sources

Synthesis and biological activity of novel shikonin analogues

Bioorganic & Medicinal Chemistry Letters, 2009
A series of shikonin analogues with side chain variants have been synthesized and evaluated for antitumor activity. These novel analogues show a broad spectrum of in vitro cytotoxicity against various cancer cell lines. Additionally, some analogues were also found to have the ability to decrease the expression level of HIF-1alpha in breast cancer cells
Wenjing, Wang, Mei, Dai, Caihua, Zhu, Jiangang, Zhang, Liping, Lin, Jian, Ding, Wenhu, Duan   +6 more
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Formal total synthesis of shikonin via Dötz benzannulation

Tetrahedron Letters, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Shon R. Pulley, Barbara Czako
openaire   +1 more source