Results 11 to 20 of about 7,326 (212)
Shikonin Inhibits Fin Regeneration in Zebrafish Larvae
Cells, 2022 Shikonin is a naphthoquinone compound extracted from Chinese comfrey for treating cancer. However, there are few reports on its research on vertebrate tissue regeneration. Zebrafish is an ideal model for studying organ regeneration.
Zigang Cao +8 more
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Anti-Leukemic Activity of Shikonin: Role of ERP57 in Shikonin Induced Apoptosis in Acute Myeloid Leukemia [PDF]
Cellular Physiology and Biochemistry, 2016 Background/Aims: ER-Stress and activation of unfolded protein response belong to the major factors involved in chemoresistance in cancer cells. In this study we investigated the effect of shikonin on the survival of acute myeloid leukemia cells and the ...
Rachana Trivedi +4 more
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Shikonin inhibits cancer cell cycling by targeting Cdc25s [PDF]
BMC Cancer, 2019 Background Shikonin, a natural naphthoquinone, is abundant in Chinese herb medicine Zicao (purple gromwell) and has a wide range of biological activities, especially for cancer.
Shoude Zhang +9 more
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Shikonin Suppresses Skin Carcinogenesis via Inhibiting Cell Proliferation.
PLoS ONE, 2015 The M2 isoform of pyruvate kinase M2 (PKM2) has been shown to be up-regulated in human skin cancers. To test whether PKM2 may be a target for chemoprevention, shikonin, a natural product from the root of Lithospermum erythrorhizon and a specific ...
Wenjuan Li +8 more
doaj +4 more sources
Promising Nanomedicines of Shikonin for Cancer Therapy
International Journal of Nanomedicine, 2023 Malignant tumor, the leading cause of death worldwide, poses a serious threat to human health. For decades, natural product has been proven to be an essential source for novel anticancer drug discovery. Shikonin (SHK), a natural molecule separated from the root of Lithospermum erythrorhizon, shows great potential in anticancer therapy.
Chunmei Yan +8 more
openaire +4 more sources
Concurrent NP-HPTLC Determination of Shikonin and β,β-Dimethylacryl Shikonin inArnebia benthamii [PDF]
Journal of Chromatographic Science, 2016 Naphthoquinones are important class of molecules found as a natural red color pigments in roots of Arnebia benthamii (Wall. ex G. Don) L M. Johnston. The aim of present investigation is to develop and validates a simple, cost-effective and reliable method for quantification of these compounds.
Preeti, Katoch +4 more
openaire +2 more sources
Shikonin Suppresses NLRP3 and AIM2 Inflammasomes by Direct Inhibition of Caspase-1. [PDF]
PLoS ONE, 2016 Shikonin is a highly lipophilic naphtoquinone found in the roots of Lithospermum erythrorhizon used for its pleiotropic effects in traditional Chinese medicine.
Jernej Zorman +2 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2022 The molecular mechanisms that regulate the proliferation and differentiation of inner ear spiral ganglion cells (SGCs) remain largely unknown. Shikonin (a naphthoquinone pigment isolated from the traditional Chinese herbal medicine comfrey root) has anti-
Hongjie Du +14 more
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Identification of onosma visianii roots extract and purified shikonin derivatives as potential acaricidal agents against tetranychus urticae [PDF]
, 2017 There is an increasing need for the discovery of reliable and eco-friendly pesticides and natural plant-derived products may play a crucial role as source of new active compounds.
Benelli, S. +7 more
core +1 more source
Journal of Translational Medicine, 2017 Background Shikonin, a natural naphthoquinone pigment purified from Lithospermum erythrorhizon, induces necroptosis in various cancer types, but the mechanisms underlying the anticancer activity of shikonin in lung cancer are not fully understood.
Hyo-Jin Kim +8 more
doaj +1 more source