Transgenic studies reveal the positive role of LeEIL-1 in regulating shikonin biosynthesis in Lithospermum erythrorhizon hairy roots [PDF]
, 2016 Time-course accumulation of shikonin in four typical hairy root lines. Value of Ei-19 or EO-13 is significantly different from that of the control line WT-1 or EV-9 at each time point from 3 to 12 days, respectively (Student’s t-test, P
Ailan Zou +13 more
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Investigating the Effects of Shikonin, Deoxyshikonin, and (β,β-Dimethylacryl)Shikonin on Melanoma Cell Lines [PDF]
Natural Product Communications, 2020 Melanoma is the most lethal form of various skin cancers and contributes to more than 79% of all skin cancer deaths. Although there are numerous therapies available for melanoma, the high rate of recurrence in melanoma post-therapy remains a challenging issue for both patients and clinicians. Apoptosis is one of the foundations for cancer treatment as
Jin Jie Dillon Ng +3 more
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An oxidative stress mechanism of shikonin in human glioma cells.
PLoS ONE, 2014 Shikonin is a quinone-containing natural product that induces the apoptotic death of some cancer cell lines in culture through increasing intracellular reactive oxygen species (ROS). Quinone-based drugs have shown potential in the clinic, making shikonin
Jen-Tsung Yang +4 more
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Beneficial effect of shikonin on experimental colitis induced by dextran sulfate sodium in Balb/C mice. [PDF]
, 2012 The naphthoquinone shikonin, a major component of the root of Lithospermum erythrorhizon, now is studied as an antiinflammatory agent in the treatment of ulcerative colitis (UC).
Andújar Pérez, Isabel +4 more
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BMC Plant Biology, 2017 Background Shikonin is a naphthoquinone secondary metabolite with important medicinal value and is found in Lithospermum erythrorhizon. Considering the limited knowledge on the membrane transport mechanism of shikonin, this study investigated such ...
Yu Zhu +9 more
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Frontiers in Pharmacology, 2022 Dysregulated immune response plays a pivotal role in Ulcerative colitis. In lamina propria of inflammatory colonic mucosa, macrophages tend to polarize into M1 type and metabolically reprogram to aerobic glycolysis.
Baoyuan Huang +8 more
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Integrative analysis of the shikonin metabolic network identifies new gene connections and reveals evolutionary insight into shikonin biosynthesis [PDF]
Horticulture Research, 2021 SummaryPlant specialized 1,4-naphthoquinones present a remarkable case of convergent evolution. Species across multiple discrete orders of vascular plants produce diverse 1,4-naphthoquinones via one of several pathways using different metabolic precursors.
Thiti Suttiyut +6 more
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Ferroxitosis: a cell death from modulation of oxidative phosphorylation and PKM2-dependent glycolysis in melanoma [PDF]
, 2014 Reliance on glycolysis is a characteristic of malignancy, yet the development of resistance to BRAF inhibitors in melanoma is associated with gain of mitochondrial function.
Brustovetsky, Nickolay +11 more
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Shikonin impairs mitochondrial activity to selectively target leukemia cells
Phytomedicine Plus, 2022 Background: Acute myeloid leukemia (AML) is a hematopoietic malignancy that results from the accumulation of undifferentiated myeloid cells in the peripheral blood and bone marrow.
Alessia Roma +9 more
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Anti-cancer natural products isolated from chinese medicinal herbs [PDF]
, 2011 In recent years, a number of natural products isolated from Chinese herbs have been found to inhibit proliferation, induce apoptosis, suppress angiogenesis, retard metastasis and enhance chemotherapy, exhibiting anti-cancer potential both in vitro and in
Wen Tan +12 more
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