Results 41 to 50 of about 7,326 (212)
miRNAs as Influencers of Cell-Cell Communication in Tumor Microenvironment [PDF]
, 2020 microRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the posttranscriptional level, inducing the degradation of the target mRNA or translational repression.
Conti, Ilaria +6 more
core +1 more source
Autocrine, paracrine and necrotic NMDA receptor signalling in mouse pancreatic neuroendocrine tumour cells. [PDF]
, 2017 N-Methyl-d-aspartate receptor (NMDAR) activation is implicated in the malignant progression of many cancer types, as previously shown by the growth-inhibitory effects of NMDAR antagonists.
Li, Leanne, Robinson, Hugh PC
core +1 more source
Chinese Medicines Induce Cell Death: The Molecular and Cellular Mechanisms for Cancer Therapy [PDF]
, 2014 published_or_final_versio
CHEUNG, F +7 more
core +3 more sources
TRAIL Enhances Shikonin Induced Apoptosis through ROS/JNK Signaling in Cholangiocarcinoma Cells
Cellular Physiology and Biochemistry, 2017 Background/Aims: Cholangiocarcinoma (CCA), arising from varying locations within the biliary tree, is the second most common primary liver malignancy worldwide.
Guangyao Zhou +4 more
doaj +1 more source
A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect [PDF]
, 2013 Cancer cells possess aberrant proteomes that can arise by the disruption of genes involved in physiological protein degradation. Here we demonstrate the presence of promoter CpG island hypermethylation-linked inactivation of DERL3 (Derlin-3), a key gene ...
Albar, Juan Pablo +27 more
core +1 more source
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Shikonin increases glucose uptake in skeletal muscle cells and improves plasma glucose levels in diabetic Goto-Kakizaki rats. [PDF]
PLoS ONE, 2011 BACKGROUND: There is considerable interest in identifying compounds that can improve glucose homeostasis. Skeletal muscle, due to its large mass, is the principal organ for glucose disposal in the body and we have investigated here if shikonin, a ...
Anette I Öberg +8 more
doaj +1 more source
Evaluation of radical scavenging properties of shikonin
Journal of Clinical Biochemistry and Nutrition, 2014 With the aim of developing effective anti-inflammatory drugs, we have been investigating the biochemical effects of shikonin of "Shikon" roots, which is a naphthoquinone with anti-inflammatory and antioxidative properties. Shikonin scavenged reactive oxygen species like hydroxyl radical, superoxide anion (O2 (•-)) and singlet oxygen in previous studies,
Yoshida, Lucia S. +6 more
openaire +3 more sources
Advanced Science, EarlyView.Schematic illustration of the synthesis protocol for Fe‐SH@Fn, an AML‐targeted nanoplatform engineered to co‐deliver shikonin (SH) and Fe3+, synergistically boosting antitumor immunity via ferroptosis induction and immunogenic cell death (ICD). ABSTRACT Acute myeloid leukemia (AML) remains a therapeutic challenge due to its low immunogenicity and ...
Shangqin Yang +9 more
wiley +1 more source
Cellular Physiology and Biochemistry, 2017 Background/Aims: Shikonin, a compound extracted from Zicao, has been demonstrated to hold anti-bacterial, anti-inflammatory, and anti-tumor activities in various diseases and it has been shown to protect human organs from injuries. However, the effect of
Yihui Bi +10 more
doaj +1 more source