Results 51 to 60 of about 7,326 (212)
Med Research, EarlyView.ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang +22 more
wiley +1 more source
Cellular Physiology and Biochemistry, 2018 Background/Aims: Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm. Tyrosine kinase inhibitors (TKIs) are commonly used to treat CML; however, drug resistance of CML cells to TKIs has limited their clinical application.
Yu Chen +10 more
doaj +1 more source
Natural Shikonin Potentially Alters Intestinal Flora to Alleviate Acute Inflammation
Microorganisms, 2023 Shikonin, derived from the herb Lithospermum erythrorhizon (Purple Cromwell), is extensively utilized in traditional Chinese medicine as an anti-inflammatory agent; however, its effect on the intestinal flora is not yet known. Herein, we demonstrate that,
Ying Liang +7 more
doaj +1 more source
, 2016 古来より紫色素は洋の東西を問わず高貴な色として尊ばれてきた｡本稿では東洋とﾖｰﾛｯﾊﾟで主に流通しているﾑﾗｻｷ科植物を取り上げて基原植物や歴史的な背景を検証した｡特にﾑﾗｻｷは日本における自生分布が広く､8～10世紀には各地で栽培が行われ大量の紫根が朝廷へ上納されていた状況について述べた｡紫根に含有する紫色素である shikonin は日本で単離構造決定されたのでそれらに付いても言及した｡さらにﾑﾗｻｷ科植物の shikonin や光学異性体の alkannin 等の生合成経路についても述べた｡又 ...
Yukihiro SHOYAMA, 正山 征洋
core +1 more source
Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy
Phytotherapy Research, EarlyView.Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee +9 more
wiley +1 more source
Broad blocking of MDR efux pumps by acetylshikonin and acetoxyisovalerylshikonin to generate hypersensitive phenotype of malignant carcinoma cells [PDF]
, 2018 Cytotoxic activities of acetylshikonin and acetoxyisovalerylshikonin alone and in combination with chemotherapeutic agents against parental and drug resistant cell lines were determined using the MTT assay.
Aliakbari, Fatemeh. +6 more
core
Unexpected one-pot synthesis of highly conjugated pentacyclic diquinoid compounds [PDF]
, 2012 A new class of pentacyclic diquinoid compounds has been synthesized with a facile one-pot reaction of two molecules of 2-hydroxynaphthoquinone and 1-bromoalkanes in the presence of ferrocene.
Bortolini, O +7 more
core +1 more source
Cell membrane‐coated nanoparticles for dermatological diseases
VIEW, EarlyView.Skin disorders are challenging to treat due to complex barrier functions and limited conventional therapies. Biomimetic cell membrane‐coated nanoparticles (CM‐NPs) offer a superior nanomedicine approach by evading immune detection and enabling precise targeting.
Shuaijun Zou, Baojie Zhang, Yuanjie Zhu
wiley +1 more source
Enzyme replacement therapies: What is the best option? [PDF]
, 2018 Despite many beneficial outcomes of the conventional enzyme replacement therapy (ERT), several limitations such as the high-cost of the treatment and various inadvertent side effects including the occurrence of an immunological response against the ...
Barar, Jaleh +4 more
core +2 more sources
ChemistryOpen, Volume 15, Issue 4, April 2026.Bioactive mesoporous silica nanoparticles (MSNPs) loaded with O. armenum extract were developed to evaluate their antibiofilm activity against biofilm‐forming Staphylococcus aureus ATCC 25923. The phytochemical content of the extract was analyzed via liquid chromatography–electrospray ionization tandem mass spectrometry.
Sevim Feyza Erdoğmuş +3 more
wiley +1 more source