Results 71 to 80 of about 7,326 (212)

The biology of PKM2 in the metabolism and senescence in diabetic kidney disease

Journal of Diabetes Investigation, Volume 17, Issue 2, Page 197-204, February 2026.
ABSTRACT Diabetic kidney disease (DKD) is one of the most common causes of chronic kidney disease that leads to end‐stage kidney disease, and its progression is closely linked to metabolic stress within renal tubular cells. Under long‐term hyperglycemia, cells shift their glucose metabolism from normal oxidative phosphorylation toward glycolysis.
Md. Imrul Kayes, Keizo Kanasaki
wiley   +1 more source

Shikonin Directly Inhibits Nitric Oxide Synthases: Possible Targets That Affect Thoracic Aorta Relaxation Response and Nitric Oxide Release From RAW 264.7 Macrophages

Journal of Pharmacological Sciences, 2010
Recently, an isomeric mixture of herbal anti-inflammatory naphthoquinones shikonin and alkannin, and their derivatives, have been found to impair cellular responses involving nitric oxide (NO) and NO synthesis, like the acetylcholine-induced relaxation ...
Lucia S. Yoshida, Tomie Kawada, Kaoru Irie, Yasukatsu Yuda, Toshiyuki Himi, Fumihiko Ikemoto, Hiromi Takano-Ohmuro   +6 more
doaj   +1 more source

Transformation of shikonin by a cell-free extract of Eubacterium sp. A-44, a human intestinal bacterium [PDF]

, 2001
For the purpose of investigating the metabolic processes of shikonin (1) by human intestinal bacteria, we prepared a sonicated bacterial cell suspension and a crude enzyme preparation from Eubacterium sp.
Akao Teruaki, Hattori Masao, MESELHY MeselhyR., Nishimoto Eri   +3 more
core   +1 more source

Stimulation of bioprocesses by ultrasound [PDF]

, 2011
Ultrasound (US) has become a ubiquitous technological process in a large variety of scientific disciplines. However, little information exists on the use of ultrasound to enhance biological processes and/or processing and consequently this paper provides
Akunna, Joseph C., Bennett, Jason, Bremner, David H., Kwiatkowska, Barbara, Walker, Graeme M.   +4 more
core   +3 more sources

Molecular Simulations of Polymer‐based Drug Nanocarriers: From Physical and Structural Properties to Controlled Release

Advanced Healthcare Materials, Volume 15, Issue 4, 26 January 2026.
Polymer‐based drug delivery systems can effectively overcome the limitations of free drugs in terms of solubility, stability, and plasma half‐life, yet their development has traditionally relied on time‐consuming trial‐and‐error approaches. This review highlights recent advances in applying molecular simulation to the design of polymer‐based drug ...
Ping Gao, Xin Jiang, Jinyu Li, Julien Nicolas, Tâp Ha‐Duong   +4 more
wiley   +1 more source

Shikonin induces apoptosis and prosurvival autophagy in human melanoma A375 cells via ROS-mediated ER stress and p38 pathways

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Shikonin, a botanical drug extracted from Lithospermum erythrorhizon, exhibits anti-cancer effects in various cancer cell lines. However, the mechanisms underlying these effects have not been completely elucidated yet.
Yongkang Liu, Xing Kang, Geng Niu, Senlin He, Tingting Zhang, Yuwei Bai, Yi Li, Houyan Hao, Chao Chen, Zhexing Shou, Bin Li   +10 more
doaj   +1 more source

Polysaccharide‐Based Food Packaging Materials: Structural Engineering, Functional Modifications, and Sustainable Applications

Macromolecular Materials and Engineering, Volume 311, Issue 1, January 2026.
Polysaccharide‐based macromolecules including starch, chitosan, cellulose, pectin, and alginate are engineered into functional packaging films through structural design and targeted chemical modifications. Reinforcement, cross‐linking, and bioactive incorporation enable enhanced mechanical performance, barrier properties, and intelligent responsiveness,
Chang Yu, Hui Sun, Lin Yao, Yunxuan Weng
wiley   +1 more source

Shikonin Attenuates Concanavalin A-Induced Acute Liver Injury in Mice via Inhibition of the JNK Pathway

Mediators of Inflammation, 2016
Objective. Shikonin possesses anti-inflammatory effects. However, its function in concanavalin A-induced acute liver injury remains uncertain. The aim of the present study was to investigate the functions of shikonin and its mechanism of protection on ...
Tong Liu, Yujing Xia, Jingjing Li, Sainan Li, Jiao Feng, Liwei Wu, Rong Zhang, Shizan Xu, Keran Cheng, Yuqing Zhou, Shunfeng Zhou, Weiqi Dai, Kan Chen, Fan Wang, Jie Lu, Yingqun Zhou, Chuanyong Guo   +16 more
doaj   +1 more source

Shikonin Prolongs Allograft Survival via Induction of CD4+FoxP3+ Regulatory T Cells

Frontiers in Immunology, 2019
A transplanted organ is usually rejected without any major immunosuppressive treatment because of vigorous alloimmune responsiveness. However, continuous global immunosuppression may cause severe side effects, including nephrotoxicity, tumors, and ...
Qiaohuang Zeng, Feifei Qiu, Yuchao Chen, Cuihua Liu, Huazhen Liu, Chun-Ling Liang, Qunfang Zhang, Zhenhua Dai   +7 more
doaj   +1 more source

Biosynthesis of Novel Shikonin Glucosides by Enzymatic Glycosylation

Chemical and Pharmaceutical Bulletin, 2019
Shikonin, a natural naphthoquinone, has attracted much attention due to its various biological activities. Two shikonin glucosides, shikonin-1',8-di-O-β-D-glucopyranoside (1) and shikonin-1'-O-β-D-glucopyranoside (2), were biosynthesized through in vitro enzymatic glycosylation and their structures were elucidated using spectroscopic techniques.
Bohan, Li, Meilin, Zhu, Hui, Ma, Tao, Ma, Yiqun, Dai, Hongmei, Li, Yu, Li, Cheng-Zhu, Wu   +7 more
openaire   +3 more sources