Results 81 to 90 of about 3,288,949 (302)

Degrading GPX4 via Biomimetic Nanoparticle‐Mediated In Situ Synthesis of Deep‐Learning‐Designed Binder‐Degron Chimeras for Prostate Cancer Therapy

Advanced Science, EarlyView.
A deep‐learning‐designed binder is fused to a combinatorial degron to create a binder‐degron chimera (bdC) that recruits the CUL2‐RING ubiquitin ligase complex. Encapsulation in a prostate‐cancer‐targeted, CD47‐camouflaged nanocarrier enables tumor‐specific in situ bdC expression, triggering GPX4 degradation and ferroptosis, thereby establishing a ...
Si‐Han Zhang, Ye An, Na Zeng, Mei‐Cheng Liu, Jian‐Xuan Sun, Xi Gong, Jin‐Zhou Xu, Shao‐Gang Wang, Qi‐Dong Xia   +8 more
wiley   +1 more source

The impact of the COVID-19 outbreak on Japanese shipping industry: An event study approach. [PDF]

Transp Policy (Oxf), 2023
Sakawa H, Watanabel N.
europepmc   +1 more source

A Scalable Droplet Microfluidic Platform That Overcomes Large‐Cell Constraints for Long‐Term Plant Cell Culture and Embryogenesis Analysis

Advanced Science, EarlyView.
This work presents a large‐cell‐compatible droplet microfluidic platform that overcomes long‐standing barriers in plant cell culture by enabling high‐fidelity encapsulation, novel multilayer 3D droplet incubation for scalable long‐term culture, and support for the full developmental progression of large plant cells.
Arman Mirmiran, Fangchi Shao, Gregory Datto, Tathansh Joshi, Elizabeth Chatt, Yashar Bashirzadeh, Dan Stessman, Lai Wei, Kuangwen Hsieh, Hena Guo, Tza‐Huei Wang   +10 more
wiley   +1 more source

Federated Learning for Maritime Environments: Use Cases, Experimental Results, and Open Issues

Journal of Marine Science and Engineering
Maritime transportation is crucial for global trade and responsible for the majority of goods movement worldwide. The optimization of maritime operations is challenged by the complexity and heterogeneity of maritime nodes.
Anastasios Giannopoulos, Panagiotis Gkonis, Petros Bithas, Nikolaos Nomikos, Alexandros Kalafatelis, Panagiotis Trakadas   +5 more
doaj   +1 more source

COVID-19 impact on the shipping industry: An event study approach. [PDF]

Transp Policy (Oxf), 2022
Gavalas D, Syriopoulos T, Tsatsaronis M.
europepmc   +1 more source

Long‐Term Human Skin Platform for Modeling Chronic Inflammation, Environmental Stress, and Therapeutic Intervention

Advanced Science, EarlyView.
An advanced, long‐term human skin platform maintains native skin structure and key tissue functions for up to four weeks. The platform models chronic inflammation, aging‐related skin changes, and UVB damage, enabling drug and topical interventions—including anti‐inflammatory therapy, senolytic treatment, and sunscreen—to be evaluated in intact human ...
Purnendu Kumar Sharma, Evelien Schaafsma, Elysia Anderson, Jocelyn Chiari, Paige Thompson, Erin Galt, Sunghoon Lee, Jason Holsapple, Sai Hein, Bailey L. Coates, Jade Michaud, Sabrina Zuccaro, Lia Kent, Chris Hinojosa, Kyung‐Jin Jang   +14 more
wiley   +1 more source

The future development and restructuring of the international shipping industry: Conference report. [PDF]

Mar Policy, 2022
Tong H.
europepmc   +1 more source

Sustainability transitions in the shipping industry

, 2016
The shipping industry contributes to several environmental problems, e.g. climate change. As any other industry, it is subjected to future restrictions for sustainable development and sustainability.
Vågfelt, Henrik
core  

A Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation

Advanced Science, EarlyView.
Cloperastine suppresses osteoclastogenesis by inhibiting PGC1β‐mediated oxidative phosphorylation. Its incorporation into a ROS‐responsive, Asp8‐modified nanoplatform enhances skeletal accumulation. The resulting Clo/Asp8‐PMK‐MCs combine cloperastine‐mediated antiresorptive activity with carrier‐mediated osteogenic activity to attenuate OVX‐induced ...
Haibo Liang, Yong Xiao, Jiangtao Luo, Xiao Yang, Yayun Yang, Qihang Wu, Chenxin Yu, Zhihao Zhou, Xiaoqing Si, Jiansen Miao, Yiting Tu, Qichen Lu, Boreng Qian, Xiangyang Wang, Jiake Xu, Changcan Shi, Haiming Jin   +16 more
wiley   +1 more source

Corporate social responsibility in the shipping/maritime industry and shipping container repurposing/recycling: is shipping container repurposing/recycling a viable example of CSR for the shipping industry?

, 2020
The need for companies in the shipping/maritime industry to establish competitive advantage through CSR has become more important. Shipping container repurposing/recycling is a logical example of a CSR practice as more sustainable solutions for retired ...
Veronica Martin 1967-
core   +1 more source